Diabetes Mellitus Predicts Cognitive Impairment in Patients with Ischemic Stroke

Overview

Journal Am J Alzheimers Dis Other Demen

Publisher Sage Publications

Specialty Neurology

Date 2010 Apr 3

PMID 20360596

Citations 10

Authors

Eliyahu Hayim Mizrahi

Ana Waitzman

Tzvia Blumstein

Marina Arad

Abraham Adunsky

Affiliations

Soon will be listed here.

Abstract

Background: Non-insulin-dependent diabetes mellitus (NIDDM) is associated with an increased incidence of cognitive impairment.

Methods: A retrospective chart review study involving 707 patients admitted for rehabilitation after an ischemic stroke. Cognitive status was assessed by the Mini-Mental State Examination (MMSE), and scores lower than 24 points were considered suggestive of cognitive impairment.

Results: Age, gender, NIDDM, dementia, and previous stroke emerged as the only statistically significant parameters differing between those with MMSE score lower than 24 or higher. After adjusting for confounding variables, NIDDM (odds ratio 1.46, 95% CI 1.05-2.05, P = .02) was associated with an increased risk of cognitive impairment.

Conclusions: Our findings suggest that NIDDM is independently associated with lower MMSE scores in ischemic stroke patients. It identifies individuals in need of specifically targeted interventions and may assist in selecting and developing resources for cognitively impaired diabetic patients.

Citing Articles

Association between diabetes mellitus and post-stroke cognitive impairment.

Lee K, Chen J, Wang C J Diabetes Investig. 2022; 14(1):6-11.

PMID: 36181402 PMC: 9807143. DOI: 10.1111/jdi.13914.

Knockdown of NRSF Alleviates Ischemic Brain Injury and Microvasculature Defects in Diabetic MCAO Mice.

He C, Xue W, Xu X, Wang J, Wang X, Feng Y Front Neurol. 2022; 13:869220.

PMID: 35645950 PMC: 9136417. DOI: 10.3389/fneur.2022.869220.

The attenuation effect of potassium 2-(1-hydroxypentyl)-benzoate in a mouse model of diabetes-associated cognitive decline: The protein expression in the brain.

Yu W, Yin H, Sun Y, Shi S, Li J, Wang X CNS Neurosci Ther. 2022; 28(7):1108-1123.

PMID: 35445545 PMC: 9160457. DOI: 10.1111/cns.13847.

Identification of an miRNA Regulatory Network and Candidate Markers for Ischemic Stroke Related to Diabetes.

Zhou H, Huang L, Liang L, Chen L, Zou C, Li Z Int J Gen Med. 2021; 14:3213-3223.

PMID: 34262334 PMC: 8274709. DOI: 10.2147/IJGM.S319503.

Dual-Tasking Effects on Gait and Turning Performance of Stroke Survivors with Diabetic Peripheral Neuropathy.

Tajuddin K, Justine M, Mohd Mustafah N, Latif L, Manaf H Malays J Med Sci. 2021; 28(2):63-71.

PMID: 33958961 PMC: 8075590. DOI: 10.21315/mjms2021.28.2.6.

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