The Range of Intrinsic Frequencies Represented by Medial Entorhinal Cortex Stellate Cells Extends with Age

Overview

Journal J Neurosci

Specialty Neurology

Date 2010 Apr 2

PMID 20357109

Citations 38

Authors

Anne Boehlen

Uwe Heinemann

Irina Erchova

Affiliations

Soon will be listed here.

Abstract

In both humans and rodents, the external environment is encoded in the form of cognitive maps. Neurons in the medial entorhinal cortex (mEC) represent spatial locations in a sequence of grid-like patterns scaled along the dorsal-ventral axis. The grid spacing correlates with the intrinsic resonance frequencies of stellate cells in layer II of mEC. We investigated the development of frequency preferences in these cells from weaning to adulthood using patch-clamp and sharp microelectrode recordings. We found that the dorsal-ventral gradient of stellate cell properties and frequency preferences exists before animals are able to actively explore their environment. In the transition to adulthood, cells respond faster and become less excitable, and the range of intrinsic resonance frequencies in the population expands in the dorsal direction. This is likely to reflect both the growth of the brain and the expansion of the internal representation caused by new exploratory experience.

Citing Articles

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