Mechanosensitivity of Ion Channels Based on Protein-lipid Interactions

Overview

Journal J R Soc Interface

Specialties Biology
Biomedical Engineering
Biophysics

Date 2010 Apr 2

PMID 20356872

Citations 25

Authors

Kenjiro Yoshimura

Masahiro Sokabe

Affiliations

Soon will be listed here.

Abstract

Ion channels form a group of membrane proteins that pass ions through a pore beyond the energy barrier of the lipid bilayer. The structure of the transmembrane segment of membrane proteins is influenced by the charges and the hydrophobicity of the surrounding lipids and the pressure on its surface. A mechanosensitive channel is specifically designed to change its conformation in response to changes in the membrane pressure (tension). However, mechanosensitive channels are not the only group that is sensitive to the physical environment of the membrane: voltage-gated channels are also amenable to the lipid environment. In this article, we review the structure and gating mechanisms of the mechanosensitive channels and voltage-gated channels and discuss how their functions are affected by the physical properties of the lipid bilayer.

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References

Guharay F, Sachs F . Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle. J Physiol. 1984; 352:685-701. PMC: 1193237. DOI: 10.1113/jphysiol.1984.sp015317. View

Anishkin A, Kamaraju K, Sukharev S . Mechanosensitive channel MscS in the open state: modeling of the transition, explicit simulations, and experimental measurements of conductance. J Gen Physiol. 2008; 132(1):67-83. PMC: 2442180. DOI: 10.1085/jgp.200810000. View

Yoshimura K, Nomura T, Sokabe M . Loss-of-function mutations at the rim of the funnel of mechanosensitive channel MscL. Biophys J. 2004; 86(4):2113-20. PMC: 1304062. DOI: 10.1016/S0006-3495(04)74270-8. View

Sukharev S, Blount P, Martinac B, Blattner F, Kung C . A large-conductance mechanosensitive channel in E. coli encoded by mscL alone. Nature. 1994; 368(6468):265-8. DOI: 10.1038/368265a0. View

MAURER J, Elmore D, Lester H, Dougherty D . Comparing and contrasting Escherichia coli and Mycobacterium tuberculosis mechanosensitive channels (MscL). New gain of function mutations in the loop region. J Biol Chem. 2000; 275(29):22238-44. DOI: 10.1074/jbc.M003056200. View

Pilot J, East J, Lee A . Effects of bilayer thickness on the activity of diacylglycerol kinase of Escherichia coli. Biochemistry. 2001; 40(28):8188-95. DOI: 10.1021/bi0103258. View

Belyy V, Anishkin A, Kamaraju K, Liu N, Sukharev S . The tension-transmitting 'clutch' in the mechanosensitive channel MscS. Nat Struct Mol Biol. 2010; 17(4):451-8. DOI: 10.1038/nsmb.1775. View

Machiyama H, Tatsumi H, Sokabe M . Structural changes in the cytoplasmic domain of the mechanosensitive channel MscS during opening. Biophys J. 2009; 97(4):1048-57. PMC: 2726311. DOI: 10.1016/j.bpj.2009.05.021. View

Liu Z, Gandhi C, Rees D . Structure of a tetrameric MscL in an expanded intermediate state. Nature. 2009; 461(7260):120-4. PMC: 2737600. DOI: 10.1038/nature08277. View

10.

Edwards M, Li Y, Kim S, Miller S, Bartlett W, Black S . Pivotal role of the glycine-rich TM3 helix in gating the MscS mechanosensitive channel. Nat Struct Mol Biol. 2005; 12(2):113-9. DOI: 10.1038/nsmb895. View

11.

Long S, Campbell E, MacKinnon R . Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science. 2005; 309(5736):897-903. DOI: 10.1126/science.1116269. View

12.

Grajkowski W, Kubalski A, Koprowski P . Surface changes of the mechanosensitive channel MscS upon its activation, inactivation, and closing. Biophys J. 2005; 88(4):3050-9. PMC: 1305397. DOI: 10.1529/biophysj.104.053546. View

13.

Yoshimura K, Usukura J, Sokabe M . Gating-associated conformational changes in the mechanosensitive channel MscL. Proc Natl Acad Sci U S A. 2008; 105(10):4033-8. PMC: 2268802. DOI: 10.1073/pnas.0709436105. View

14.

Freites J, Tobias D, von Heijne G, White S . Interface connections of a transmembrane voltage sensor. Proc Natl Acad Sci U S A. 2005; 102(42):15059-64. PMC: 1250233. DOI: 10.1073/pnas.0507618102. View

15.

Edwards M, Bartlett W, Booth I . Pore mutations of the Escherichia coli MscS channel affect desensitization but not ionic preference. Biophys J. 2007; 94(8):3003-13. PMC: 2275705. DOI: 10.1529/biophysj.107.123448. View

16.

Cuello L, Cortes D, Perozo E . Molecular architecture of the KvAP voltage-dependent K+ channel in a lipid bilayer. Science. 2004; 306(5695):491-5. DOI: 10.1126/science.1101373. View

17.

Aggarwal S, Mackinnon R . Contribution of the S4 segment to gating charge in the Shaker K+ channel. Neuron. 1996; 16(6):1169-77. DOI: 10.1016/s0896-6273(00)80143-9. View

18.

Nishida M, Cadene M, Chait B, MacKinnon R . Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. EMBO J. 2007; 26(17):4005-15. PMC: 1994128. DOI: 10.1038/sj.emboj.7601828. View

19.

Traikia M, Warschawski D, Lambert O, Rigaud J, Devaux P . Asymmetrical membranes and surface tension. Biophys J. 2002; 83(3):1443-54. PMC: 1302243. DOI: 10.1016/S0006-3495(02)73915-5. View

20.

Iscla I, Wray R, Blount P . On the structure of the N-terminal domain of the MscL channel: helical bundle or membrane interface. Biophys J. 2008; 95(5):2283-91. PMC: 2517020. DOI: 10.1529/biophysj.107.127423. View