HIV-1 Transmission, Replication Fitness and Disease Progression

Overview

Journal Virology (Auckl)

Publisher Sage Publications

Specialty Microbiology

Date 2010 Apr 1

PMID 20354593

Citations 6

Authors

Tasha Biesinger

Jason T Kimata

Affiliations

Soon will be listed here.

Abstract

Upon transmission, human immunodeficiency virus type 1 (HIV-1) establishes infection of the lymphatic reservoir, leading to profound depletion of the memory CD4(+) T cell population, despite the induction of the adaptive immune response. The rapid evolution and association of viral variants having distinct characteristics with different stages of infection, the level of viral burden, and rate of disease progression suggest a role for viral variants in this process. Here, we review the literature on HIV-1 variants and disease and discuss the importance of viral fitness for transmission and disease.

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