Site-specific Recombination Between Homologous Chromosomes in Drosophila

Overview

Journal Science

Specialty Science

Date 1991 May 17

PMID 2035025

Citations 153

Authors

K G Golic

Affiliations

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Abstract

The ability to mark a cell and its descendants genetically so that the resulting cell clone can be distinguished from neighboring cells facilitates studies in animal biology and development. A method of generating clones by inducing homologous mitotic recombination in Drosophila with a site-specific yeast recombinase is described. This method allows for frequent mosaicism after mitotic exchange is induced at predefined sites in the genome.

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