Innate Immune Detection of Bacterial Virulence Factors Via the NLRC4 Inflammasome

Overview

Journal J Clin Immunol

Publisher Springer

Specialty Allergy & Immunology

Date 2010 Mar 30

PMID 20349122

Citations 46

Authors

Edward A Miao

Sarah E Warren

Affiliations

Soon will be listed here.

Abstract

Introduction: Cytokine production by innate immune cells is initiated by signaling downstream of pattern recognition receptors, including Toll-like receptors.

Discussion: A subset of cytokines, including IL-1beta and IL-18, require post-translational proteolysis before secretion, which provides a second mechanism of regulation. This proteolysis is dependent upon caspase 1, which is activated by Nod-like receptor (NLR) signaling. NLRC4 (previously named Ipaf) activates caspase 1 in response to bacterial virulence factors including type III and IV secretion systems (T3SS and T4SS). NLRC4 recognizes T3SS/T4SS in two ways: indirectly by detecting flagellin, and directly by detecting the T3SS rod protein. Both flagellin and rod protein are unintentionally delivered to the mammalian cytosol by the bacterium through the T3SS.

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