The Major 85-kDa Surface Antigen of the Mammalian-stage Forms of Trypanosoma Cruzi is a Family of Sialidases

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1991 May 15

PMID 2034687

Citations 21

Authors

S Kahn

T G Colbert

J C Wallace

N A Hoagland

H Eisen

Affiliations

Soon will be listed here.

Abstract

Trypanosoma cruzi, an intracellular protozoan parasite infecting a wide variety of vertebrates, is the agent responsible for Chagas disease in humans. An estimated 15-20 million people in South and Central America are infected with the parasite. Chagas disease often results in severe autoimmune and inflammatory pathology and is the major cause of heart failure in endemic areas. Nevertheless, little is known about the host-parasite interactions that lead to this pathology. We have previously cloned several members of a large gene family (SA85-1) and shown that these genes encode 85-kDa T. cruzi, mammalian-stage-specific, surface antigens. Here we report that members of the SA85-1 family possess sialidase activity and are shed by the parasite. We suggest that the sialidases may contribute to the pathology during T. cruzi infection by cleaving sialic acid from cells of the immune system.

Citing Articles

A Brief View of the Surface Membrane Proteins from .

Pech-Canul A, Monteon V, Solis-Oviedo R J Parasitol Res. 2017; 2017:3751403.

PMID: 28656101 PMC: 5474541. DOI: 10.1155/2017/3751403.

Protein kinase A catalytic subunit interacts and phosphorylates members of trans-sialidase super-family in Trypanosoma cruzi.

Bao Y, Weiss L, Ma Y, Kahn S, Huang H Microbes Infect. 2010; 12(10):716-26.

PMID: 20466066 PMC: 2934751. DOI: 10.1016/j.micinf.2010.04.014.

Lateral flow immunoassay for diagnosis of Trypanosoma cruzi infection with high correlation to the radioimmunoprecipitation assay.

Houghton R, Stevens Y, Hjerrild K, Guderian J, Okamoto M, Kabir M Clin Vaccine Immunol. 2009; 16(4):515-20.

PMID: 19211772 PMC: 2668284. DOI: 10.1128/CVI.00383-08.

During Trypanosoma cruzi infection CD1d-restricted NK T cells limit parasitemia and augment the antibody response to a glycophosphoinositol-modified surface protein.

Duthie M, Wleklinski-Lee M, Smith S, Nakayama T, Taniguchi M, Kahn S Infect Immun. 2001; 70(1):36-48.

PMID: 11748161 PMC: 127608. DOI: 10.1128/IAI.70.1.36-48.2002.

Epitope mapping of trans-sialidase from Trypanosoma cruzi reveals the presence of several cross-reactive determinants.

Pitcovsky T, Mucci J, Alvarez P, Leguizamon M, Burrone O, Alzari P Infect Immun. 2001; 69(3):1869-75.

PMID: 11179365 PMC: 98094. DOI: 10.1128/IAI.69.3.1869-1875.2001.

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