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Polycomb Group Protein-mediated Repression of Transcription

Overview
Specialty Biochemistry
Date 2010 Mar 30
PMID 20346678
Citations 197
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Abstract

The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.

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