Effects of a Novel Arginine Methyltransferase Inhibitor on T-helper Cell Cytokine Production

Overview

Journal FEBS J

Specialty Biochemistry

Date 2010 Mar 30

PMID 20345902

Citations 31

Authors

Kevin Bonham

Saskia Hemmers

Yeon-Hee Lim

Dawn M Hill

M G Finn

Kerri A Mowen

Affiliations

Soon will be listed here.

Abstract

The protein arginine methyltransferase (PRMT) family of enzymes catalyzes the transfer of methyl groups from S-adenosylmethionine to the guanidino nitrogen atom of peptidylarginine to form monomethylarginine or dimethylarginine. We created several less polar analogs of the specific PRMT inhibitor arginine methylation inhibitor-1, and one such compound was found to have improved PRMT inhibitory activity over the parent molecule. The newly identified PRMT inhibitor modulated T-helper-cell function and thus may serve as a lead for further inhibitors useful for the treatment of immune-mediated disease.

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