Neural Mechanisms of Ageing and Cognitive Decline

Overview

Journal Nature

Specialty Science

Date 2010 Mar 26

PMID 20336135

Citations 546

Authors

Nicholas A Bishop

Tao Lu

Bruce A Yankner

Affiliations

Soon will be listed here.

Abstract

During the past century, treatments for the diseases of youth and middle age have helped raise life expectancy significantly. However, cognitive decline has emerged as one of the greatest health threats of old age, with nearly 50% of adults over the age of 85 afflicted with Alzheimer's disease. Developing therapeutic interventions for such conditions demands a greater understanding of the processes underlying normal and pathological brain ageing. Recent advances in the biology of ageing in model organisms, together with molecular and systems-level studies of the brain, are beginning to shed light on these mechanisms and their potential roles in cognitive decline.

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