Infant Pathways to Externalizing Behavior: Evidence of Genotype X Environment Interaction

Overview

Journal Child Dev

Specialty Pediatrics

Date 2010 Mar 25

PMID 20331671

Citations 36

Authors

Leslie D Leve

David C R Kerr

Daniel Shaw

Xiaojia Ge

Jenae M Neiderhiser

Laura V Scaramella

John B Reid

Rand Conger

David Reiss

Affiliations

Soon will be listed here.

Abstract

To further the understanding of the effects of early experiences, 9-month-old infants were observed during a frustration task. The analytical sample was composed of 348 linked triads of participants (adoptive parents, adopted child, and birth parent[s]) from a prospective adoption study. It was hypothesized that genetic risk for externalizing problems and affect dysregulation in the adoptive parents would independently and interactively predict a known precursor to externalizing problems: heightened infant attention to frustrating events. Results supported the moderation hypotheses involving adoptive mother affect dysregulation: Infants at genetic risk showed heightened attention to frustrating events only when the adoptive mother had higher levels of anxious and depressive symptoms. The Genotype x Environment interaction pattern held when substance use during pregnancy was considered.

Citing Articles

Early risk for child externalising symptoms: Examining genetic, prenatal, temperamental and parental influences.

Lee S, Robertson O, Marceau K, Knopik V, Natsuaki M, Shaw D Infant Child Dev. 2024; 33(4).

PMID: 39183803 PMC: 11339911. DOI: 10.1002/icd.2508.

Parenting in the Context of the Child: Genetic and Social Processes.

Reiss D, Ganiban J, Leve L, Neiderhiser J, Shaw D, Natsuaki M Monogr Soc Res Child Dev. 2023; 87(1-3):7-188.

PMID: 37070594 PMC: 10329459. DOI: 10.1111/mono.12460.

Developmental profiles of child behavior problems from 18 months to 8 years: The protective effects of structured parenting vary by genetic risk.

Leve L, Anderson D, Harold G, Neiderhiser J, Natsuaki M, Shaw D Dev Psychopathol. 2022; 34(5):1716-1730.

PMID: 35929354 PMC: 9899296. DOI: 10.1017/S0954579422000839.

Examining Research Domain Criteria (RDoC) constructs for anger expression and regulation in toddlers.

Liu C, Moore G, Roben C, Ganiban J, Leve L, Shaw D J Psychopathol Clin Sci. 2022; 131(6):588-597.

PMID: 35901390 PMC: 9439578. DOI: 10.1037/abn0000658.

Reducing Poverty-Related Disparities in Child Development and School Readiness: The Smart Beginnings Tiered Prevention Strategy that Combines Pediatric Primary Care with Home Visiting.

Shaw D, Mendelsohn A, Morris P Clin Child Fam Psychol Rev. 2021; 24(4):669-683.

PMID: 34505232 PMC: 8428206. DOI: 10.1007/s10567-021-00366-0.

References

Shackman J, Shackman A, Pollak S . Physical abuse amplifies attention to threat and increases anxiety in children. Emotion. 2007; 7(4):838-52. DOI: 10.1037/1528-3542.7.4.838. View

Shaw D, Dishion T, Supplee L, Gardner F, Arnds K . Randomized trial of a family-centered approach to the prevention of early conduct problems: 2-year effects of the family check-up in early childhood. J Consult Clin Psychol. 2006; 74(1):1-9. DOI: 10.1037/0022-006X.74.1.1. View

Caspi A, McClay J, Moffitt T, Mill J, Martin J, Craig I . Role of genotype in the cycle of violence in maltreated children. Science. 2002; 297(5582):851-4. DOI: 10.1126/science.1072290. View

Cicchetti D, Rogosch F, Toth S . Maternal depressive disorder and contextual risk: contributions to the development of attachment insecurity and behavior problems in toddlerhood. Dev Psychopathol. 1998; 10(2):283-300. DOI: 10.1017/s0954579498001618. View

Shaw D, Connell A, Dishion T, Wilson M, Gardner F . Improvements in maternal depression as a mediator of intervention effects on early childhood problem behavior. Dev Psychopathol. 2009; 21(2):417-39. PMC: 2770003. DOI: 10.1017/S0954579409000236. View

Posner M, Petersen S . The attention system of the human brain. Annu Rev Neurosci. 1990; 13:25-42. DOI: 10.1146/annurev.ne.13.030190.000325. View

Rhee S, Waldman I . Genetic and environmental influences on antisocial behavior: a meta-analysis of twin and adoption studies. Psychol Bull. 2002; 128(3):490-529. View

Shaw D, Winslow E, Owens E, Vondra J, Cohn J, BELL R . The development of early externalizing problems among children from low-income families: a transformational perspective. J Abnorm Child Psychol. 1998; 26(2):95-107. DOI: 10.1023/a:1022665704584. View

van IJzendoorn M, Juffer F . The Emanuel Miller Memorial Lecture 2006: adoption as intervention. Meta-analytic evidence for massive catch-up and plasticity in physical, socio-emotional, and cognitive development. J Child Psychol Psychiatry. 2006; 47(12):1228-45. DOI: 10.1111/j.1469-7610.2006.01675.x. View

10.

Leve L, Neiderhiser J, Ge X, Scaramella L, Conger R, Reid J . The early growth and development study: a prospective adoption design. Twin Res Hum Genet. 2007; 10(1):84-95. PMC: 4169207. DOI: 10.1375/twin.10.1.84. View

11.

Forget-Dubois N, Boivin M, Dionne G, Pierce T, Tremblay R, Perusse D . A longitudinal twin study of the genetic and environmental etiology of maternal hostile-reactive behavior during infancy and toddlerhood. Infant Behav Dev. 2007; 30(3):453-65. DOI: 10.1016/j.infbeh.2006.12.005. View

12.

Downey G, Coyne J . Children of depressed parents: an integrative review. Psychol Bull. 1990; 108(1):50-76. DOI: 10.1037/0033-2909.108.1.50. View

13.

Laucht M, Becker K, Schmidt M . Visual exploratory behaviour in infancy and novelty seeking in adolescence: two developmentally specific phenotypes of DRD4?. J Child Psychol Psychiatry. 2006; 47(11):1143-51. DOI: 10.1111/j.1469-7610.2006.01627.x. View

14.

Tuvblad C, Grann M, Lichtenstein P . Heritability for adolescent antisocial behavior differs with socioeconomic status: gene-environment interaction. J Child Psychol Psychiatry. 2006; 47(7):734-43. DOI: 10.1111/j.1469-7610.2005.01552.x. View

15.

Miles D, Carey G . Genetic and environmental architecture of human aggression. J Pers Soc Psychol. 1997; 72(1):207-17. DOI: 10.1037//0022-3514.72.1.207. View

16.

Lyons-Ruth K, Easterbrooks M, Cibelli C . Infant attachment strategies, infant mental lag, and maternal depressive symptoms: predictors of internalizing and externalizing problems at age 7. Dev Psychol. 1997; 33(4):681-92. DOI: 10.1037//0012-1649.33.4.681. View

17.

Ge X, Natsuaki M, Martin D, Leve L, Neiderhiser J, Shaw D . Bridging the divide: openness in adoption and postadoption psychosocial adjustment among birth and adoptive parents. J Fam Psychol. 2008; 22(4):529-40. PMC: 2638763. DOI: 10.1037/a0012817. View

18.

Blair C . Early intervention for low birth weight, preterm infants: the role of negative emotionality in the specification of effects. Dev Psychopathol. 2002; 14(2):311-32. DOI: 10.1017/s0954579402002079. View

19.

Thapar A, ODonovan M, Owen M . The genetics of attention deficit hyperactivity disorder. Hum Mol Genet. 2005; 14 Spec No. 2:R275-82. DOI: 10.1093/hmg/ddi263. View

20.

Smeekens S, Riksen-Walraven J, van Bakel H . Multiple determinants of externalizing behavior in 5-year-olds: a longitudinal model. J Abnorm Child Psychol. 2007; 35(3):347-61. PMC: 1915644. DOI: 10.1007/s10802-006-9095-y. View