Effect of Propionyl-L-carnitine on Mechanical Function of Isolated Rabbit Heart

Overview

Journal Cardiovasc Drugs Ther

Specialties Cardiology & Vascular Diseases
Pharmacology

Date 1991 Feb 1

PMID 2031870

Citations 5

Authors

R Ferrari

E Pasini

E Condorelli

A Boraso

R Lisciani

A Marzo

O Visiou

Affiliations

Soon will be listed here.

Abstract

We studied the acute and chronic effects of propionyl-L-carnitine (PLC) on mechanical function of isolated rabbit heart. Propionyl-L-carnitine was either directly delivered in the perfusate (10(-9) to 10(-3) M) or intraperitoneally injected (250 mg/kg) for 10 days to the animals. When added acutely, propionyl-L-carnitine had no effect on inotropism, heart rate, or coronary perfusion pressure. When added chronically, propionyl-L-carnitine induced a positive inotropic effect, with no changes in heart rate or in coronary perfusion pressure, and it ameliorated the pressure-volume relationship. This effect of propionyl-L-carnitine was independent of the calcium concentration of the perfusion medium, but it was correlated with an increase in the myocardial content of propionyl-L-carnitine. The effect was not apparent after 5 days of treatment, although the tissue content of propionyl-L-carnitine remained unchanged. These data suggest that propionyl-L-carnitine, when given chronically, exerts a positive inotropic effect.

Citing Articles

Effects of L-carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts.

Cui J, Das D, Bertelli A, Tosaki A Mol Cell Biochem. 2003; 254(1-2):227-34.

PMID: 14674702 DOI: 10.1023/a:1027368018064.

Effects of L-carnitine and its acetyl and propionyl esters on ATP and PCr levels of isolated rat hearts perfused without fatty acids and investigated by means of 31P-NMR spectroscopy.

Loster H, Keller T, Grommisch J, Grunder W Mol Cell Biochem. 1999; 200(1-2):93-102.

PMID: 10569188 DOI: 10.1023/a:1006966817286.

Assessment of the cardiostimulant action of propionyl-L-carnitine on chronically volume-overloaded rat hearts.

Bouhaddioni N, Moravec J Cardiovasc Drugs Ther. 1993; 7(3):357-63.

PMID: 8364005 DOI: 10.1007/BF00880159.

Effect of prolonged treatment with propionyl-L-carnitine on erucic acid-induced myocardial dysfunction in rats.

Pasini E, Cargnoni A, Condorelli E, Marzo A, Lisciani R, Ferrari R Mol Cell Biochem. 1992; 112(2):117-23.

PMID: 1640928 DOI: 10.1007/BF00227568.

L-propionylcarnitine and myocardial performance in stunned porcine myocardium.

Sassen L, Duncker D, Hogendoorn A, McFalls E, Krams R, Bezstarosti K Mol Cell Biochem. 1992; 116(1-2):147-53.

PMID: 1480143 DOI: 10.1007/BF01270582.

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