The Population Genetics of Beneficial Mutations

Overview

Journal Philos Trans R Soc Lond B Biol Sci

Specialty Biology

Date 2010 Mar 24

PMID 20308094

Citations 64

Authors

H Allen Orr

Affiliations

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Abstract

The population genetic study of advantageous mutations has lagged behind that of deleterious and neutral mutations. But over the past two decades, a number of significant developments, both theoretical and empirical, have occurred. Here, I review two of these developments: the attempt to determine the distribution of fitness effects among beneficial mutations and the attempt to determine their average dominance. Considering both theory and data, I conclude that, while considerable theoretical progress has been made, we still lack sufficient data to draw confident conclusions about the distribution of effects or the dominance of beneficial mutations.

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