Mitochondrial DNA Alterations and Reduced Mitochondrial Function in Aging

Overview

Journal Mech Ageing Dev

Specialty Geriatrics

Date 2010 Mar 24

PMID 20307565

Citations 38

Authors

Sadie L Hebert

Ian R Lanza

K Sreekumaran Nair

Affiliations

Soon will be listed here.

Abstract

Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondrial DNA alterations and changes in mitochondrial function that occur with aging. Age-related alterations in mitochondrial DNA as a possible contributor to the reduction in mitochondrial function are discussed.

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