Role of Infection in the Development and Exacerbation of Asthma

Overview

Journal Expert Rev Respir Med

Specialty Pulmonary Medicine

Date 2010 Mar 23

PMID 20305826

Citations 29

Authors

Theresa W Guilbert

Loren C Denlinger

Affiliations

Soon will be listed here.

Abstract

Respiratory infections are associated with wheezing illnesses in all ages and may also impact the development and severity of asthma. Respiratory tract infections caused by viruses, Chlamydophila or Mycoplasma have been hypothesized to have significant roles in the pathogenesis of asthma. Progress is being made toward establishing the mechanisms by which these agents can cause acute wheezing and impact the pathophysiology of asthma. Host factors probably contribute to the risk of asthma inception and exacerbation, and these contributions may also vary with respect to early- versus adult-onset disease. This review discusses these various associations as they pertain to the development and exacerbation of asthma.

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References

MACEK V, Sorli J, Kopriva S, Marin J . Persistent adenoviral infection and chronic airway obstruction in children. Am J Respir Crit Care Med. 1994; 150(1):7-10. DOI: 10.1164/ajrccm.150.1.8025775. View

Martin R, Kraft M, Chu H, Berns E, Cassell G . A link between chronic asthma and chronic infection. J Allergy Clin Immunol. 2001; 107(4):595-601. DOI: 10.1067/mai.2001.113563. View

Albanesi C, Fairchild H, Madonna S, Scarponi C, De Pita O, Leung D . IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3. J Immunol. 2007; 179(2):984-92. DOI: 10.4049/jimmunol.179.2.984. View

Malmstrom K, Pitkaranta A, Carpen O, Pelkonen A, Malmberg L, Turpeinen M . Human rhinovirus in bronchial epithelium of infants with recurrent respiratory symptoms. J Allergy Clin Immunol. 2006; 118(3):591-6. DOI: 10.1016/j.jaci.2006.04.032. View

Lee W, Kiesner C, Pappas T, Lee I, Grindle K, Jartti T . A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants. PLoS One. 2007; 2(10):e966. PMC: 1989136. DOI: 10.1371/journal.pone.0000966. View

Castro-Rodriguez J, Holberg C, Wright A, Martinez F . A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med. 2000; 162(4 Pt 1):1403-6. DOI: 10.1164/ajrccm.162.4.9912111. View

Lemanske Jr R, Busse W . 6. Asthma: Factors underlying inception, exacerbation, and disease progression. J Allergy Clin Immunol. 2006; 117(2 Suppl Mini-Primer):S456-61. PMC: 7119312. DOI: 10.1016/j.jaci.2005.07.006. View

Dales R, Schweitzer I, Toogood J, Drouin M, Yang W, Dolovich J . Respiratory infections and the autumn increase in asthma morbidity. Eur Respir J. 1996; 9(1):72-7. DOI: 10.1183/09031936.96.09010072. View

Harju T, Leinonen M, Nokso-Koivisto J, Korhonen T, Raty R, He Q . Pathogenic bacteria and viruses in induced sputum or pharyngeal secretions of adults with stable asthma. Thorax. 2006; 61(7):579-84. PMC: 2104650. DOI: 10.1136/thx.2005.056291. View

10.

Kusel M, de Klerk N, Kebadze T, Vohma V, Holt P, Johnston S . Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol. 2007; 119(5):1105-10. PMC: 7125611. DOI: 10.1016/j.jaci.2006.12.669. View

11.

Kelly J, Busse W . Host immune responses to rhinovirus: mechanisms in asthma. J Allergy Clin Immunol. 2008; 122(4):671-682. PMC: 3927944. DOI: 10.1016/j.jaci.2008.08.013. View

12.

Johnston S, Pattemore P, SANDERSON G, Smith S, Lampe F, Josephs L . Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ. 1995; 310(6989):1225-9. PMC: 2549614. DOI: 10.1136/bmj.310.6989.1225. View

13.

Idzko M, Hammad H, van Nimwegen M, Kool M, Willart M, Muskens F . Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat Med. 2007; 13(8):913-9. DOI: 10.1038/nm1617. View

14.

Papadopoulos N, Bates P, Bardin P, Papi A, Leir S, Fraenkel D . Rhinoviruses infect the lower airways. J Infect Dis. 2000; 181(6):1875-84. DOI: 10.1086/315513. View

15.

Bastian A, Schafer H . Human alpha-defensin 1 (HNP-1) inhibits adenoviral infection in vitro. Regul Pept. 2001; 101(1-3):157-61. DOI: 10.1016/s0167-0115(01)00282-8. View

16.

Bochkov Y, Hanson K, Keles S, Brockman-Schneider R, Jarjour N, Gern J . Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma. Mucosal Immunol. 2009; 3(1):69-80. PMC: 2884103. DOI: 10.1038/mi.2009.109. View

17.

Noma T, Mori A, Yoshizawa I . Induction of allergen-specific IL-2 responsiveness of lymphocytes after respiratory syncytial virus infection and prediction of onset of recurrent wheezing and bronchial asthma. J Allergy Clin Immunol. 1996; 98(4):816-26. DOI: 10.1016/s0091-6749(96)70131-8. View

18.

Carroll K, Wu P, Gebretsadik T, Griffin M, Dupont W, Mitchel E . The severity-dependent relationship of infant bronchiolitis on the risk and morbidity of early childhood asthma. J Allergy Clin Immunol. 2009; 123(5):1055-61, 1061.e1. PMC: 2703291. DOI: 10.1016/j.jaci.2009.02.021. View

19.

Sakamoto M, Ida S, Takishima T . Effect of influenza virus infection on allergic sensitization to aerosolized ovalbumin in mice. J Immunol. 1984; 132(5):2614-7. View

20.

Willart M, Lambrecht B . The danger within: endogenous danger signals, atopy and asthma. Clin Exp Allergy. 2008; 39(1):12-9. DOI: 10.1111/j.1365-2222.2008.03118.x. View