Non-immune Goiter and Hypothyroidism in a 19-week Fetus: a Plea for Conservative Treatment

Overview

Journal J Pediatr

Specialty Pediatrics

Date 2010 Mar 23

PMID 20304420

Citations 7

Authors

Sophie Stoppa-Vaucher

Diane Francoeur

Andree Grignon

Nathalie Alos

Joachim Pohlenz

Pia Hermanns

Guy Van Vliet

Johnny Deladoey

Affiliations

Soon will be listed here.

Abstract

Hypothyroidism was documented by cordocentesis at 19 weeks in a fetus with non-immune goiter. Intra-amniotic thyroxine was injected at 25 weeks when amniotic fluid volume increased. Psychomotor outcome was normal. We argue that intra-amniotic thyroxine should not be used to treat the hypothyroidism but only to correct the development of polyhydramnios.

Citing Articles

Intra-amniotic levothyroxine infusions in a case of fetal goiter due to novel gene variants.

Polle O, Gheldof A, Lysy P, Bernard P Clin Case Rep. 2021; 9(9):e04565.

PMID: 34484748 PMC: 8405428. DOI: 10.1002/ccr3.4565.

Case Report: Functional Analysis and Neuropsychological Evaluation of Dyshormonogenetic Fetal Goiter in Siblings Caused by Novel Compound Hyterozygous TPO Gene Mutations.

Rodrigues T, Silva M, Freitas M, Duarte Z, Frutuoso V, Rodrigues M Front Endocrinol (Lausanne). 2021; 12:671659.

PMID: 34220711 PMC: 8251258. DOI: 10.3389/fendo.2021.671659.

Conservative treatment of fetal dyshormonogenetic goiter with levothyroxine, a systematic literature review.

Nemescu D, Tanasa I, Stoian D, Navolan D, Elena Vinturache A Exp Ther Med. 2020; 20(3):2434-2438.

PMID: 32765729 PMC: 7401841. DOI: 10.3892/etm.2020.8794.

Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis.

Figueiredo C, Falcao I, Vilaverde J, Freitas J, Oliveira M, Godinho C Case Rep Endocrinol. 2019; 2018:9564737.

PMID: 30662777 PMC: 6313984. DOI: 10.1155/2018/9564737.

Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation.

Vasudevan P, Powell C, Nicholas A, Scudamore I, Greening J, Park S Endocrinol Diabetes Metab Case Rep. 2017; 2017.

PMID: 28620499 PMC: 5467655. DOI: 10.1530/EDM-17-0040.