Cytokines and Other Mediators in Alopecia Areata

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2010 Mar 20

PMID 20300578

Citations 42

Authors

Stamatis Gregoriou

Dafni Papafragkaki

George Kontochristopoulos

Eustathios Rallis

Dimitrios Kalogeromitros

Dimitris Rigopoulos

Affiliations

Soon will be listed here.

Abstract

Alopecia areata, a disease of the hair follicles with multifactorial etiology and a strong component of autoimmune origin, has been extensively studied as far as the role of several cytokines is concerned. So far, IFN-gamma, interleukins, TNF-alpha, are cytokines that are well known to play a major role in the pathogenesis of the disease, while several studies have shown that many more pathways exist. Among them, MIG, IP-10, BAFF, HLA antigens, MIG, as well as stress hormones are implicated in disease onset and activity. Within the scope of this paper, the authors attempt to shed light upon the complexity of alopecia areata underlying mechanisms and indicate pathways that may suggest future treatments.

Citing Articles

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