Prevalence of Ocular Fundus Pathology in Patients with Chronic Kidney Disease

Overview

Journal Clin J Am Soc Nephrol

Specialty Nephrology

Date 2010 Mar 20

PMID 20299372

Citations 36

Authors

Juan E Grunwald

Judith Alexander

Maureen Maguire

Revell Whittock

Candace Parker

Kathleen McWilliams

Joan C Lo

Raymond Townsend

Crystal A Gadegbeku

James P Lash

Jeffrey C Fink

Mahaboob Rahman

Harold Feldman

John Kusek

Akinlolu Ojo

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: The objective of this study was to describe the prevalence of ocular fundus pathology in the Chronic Renal Insufficiency Cohort (CRIC) study, a multicenter, longitudinal study of individuals with varying stages of chronic kidney disease (CKD).

Design, Setting, Participants, & Measurements: In this cross-sectional study, 45 degree digital photos of the disc and macula in both eyes were obtained by nonophthalmologic personnel using a nonmydriatic Canon CR-DGI fundus camera in 1936 individuals who participated in the CRIC study. Photographs were assessed in a masked manner by graders and a retinal specialist at a central photograph reading center. The purpose of this review was to inform participants quickly of conditions that warranted a complete eye examination by an ophthalmologist.

Results: Among the 1936 participants who were photographed, 1904 (98%) had assessable photographs in at least one eye. Eye pathologies that required a follow-up examination by an ophthalmologist were identified in 864 (45%) of these 1904 participants. These eye pathologies included, among others, retinopathy (diabetic and/or hypertensive), a finding that was observed in 482 (25%) of these 1904 participants. Three percent (65 participants) of the 1904 participants had serious eye conditions that required urgent follow-up and treatment. Lower estimated GFR and cardiovascular disease were associated with greater eye pathology. Estimated GFR <30 ml/min per 1.73 m(2) was associated with a three times higher risk for retinopathy.

Conclusions: We found a high prevalence of fundus pathology in participants with CKD. This finding supports recommendations for regular complete eye examinations in the CKD population.

Citing Articles

Diagnosis of Chronic Kidney Disease Using Retinal Imaging and Urine Dipstick Data: Multimodal Deep Learning Approach.

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Evaluating the potential of retinal photography in chronic kidney disease detection: a review.

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Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment.

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Moshegov S, Seth I, Wawryk O, Sandhu S, Lanteri M, Baird P J Curr Ophthalmol. 2023; 35(1):66-72.

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