Hyaluronan Induces Migration of Multidrug-resistant Lymphoma Cell Lines in Vitro Through Tiam1 Activation by a PI3K-dependent Mechanism

Overview

Journal Leuk Res

Date 2010 Mar 20

PMID 20299090

Citations 5

Authors

Rosalia I Cordo-Russo

Laura D Alaniz

Natalia Saccodossi

Silvina Lompardia

Guillermo Blanco

Elida Alvarez

Mariana G Garcia

Silvia E Hajos

Affiliations

Soon will be listed here.

Abstract

Hyaluronan (HA) modulates multidrug resistance (MDR) as well as cell migration. Tiam1 is involved in cytoskeleton reorganization during tumor invasion. In this report we show the relationship among HA, Tiam1, migration and MDR in murine lymphoma cell lines. We observed that MDR cells presented higher migratory capacity towards HA in vitro as well as higher constitutive active Tiam1 expression than the sensitive cell line. Besides, HA treatment induced migration towards HA of MDR cell lines through Tiam1 activation by a PI3K-dependent mechanism, showing that disruption of HA signaling would be useful in treatment of MDR hematological malignancies.

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