Where Do Adult Leydig Cells Come From?

Overview

Journal Biol Reprod

Publisher Oxford University Press

Specialty Reproductive Medicine

Date 2010 Mar 19

PMID 20237331

Citations 7

Authors

Barry R Zirkin

Affiliations

Soon will be listed here.

Citing Articles

Neonatal exposure to high D-galactose affects germ cell development in neonatal testes organ culture.

Song H, Han M, Lee R, Park H Sci Rep. 2024; 14(1):24029.

PMID: 39402149 PMC: 11473950. DOI: 10.1038/s41598-024-74895-3.

Differentiation of human umbilical cord mesenchymal stem cells into Leydig-like cells with defined molecular compounds.

Ji W, Chen Y, Wang L, Xu Z, Ahmed J, Ge R Hum Cell. 2020; 33(2):318-329.

PMID: 32034722 DOI: 10.1007/s13577-020-00324-y.

Differentiation of human adipose derived stem cells into Leydig-like cells with molecular compounds.

Chen Y, Li C, Ji W, Wang L, Chen X, Zhao S J Cell Mol Med. 2019; 23(9):5956-5969.

PMID: 31293077 PMC: 6714210. DOI: 10.1111/jcmm.14427.

Differentiation of human umbilical cord mesenchymal stem cells into steroidogenic cells .

Xing X, Zhang Z, Zhong L, Ju G, Zou X, Zhu Y Exp Ther Med. 2017; 12(6):3527-3534.

PMID: 28105086 PMC: 5228511. DOI: 10.3892/etm.2016.3815.

Time course and role of luteinizing hormone and follicle-stimulating hormone in the expansion of the Leydig cell population at the time of puberty in the rhesus monkey (Macaca mulatta).

Verhagen I, Ramaswamy S, Teerds K, Keijer J, Plant T Andrology. 2014; 2(6):924-30.

PMID: 25269763 PMC: 4205165. DOI: 10.1111/andr.275.

References

Zhang F, Poutanen M, Wilbertz J, Huhtaniemi I . Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice. Mol Endocrinol. 2001; 15(1):172-83. DOI: 10.1210/mend.15.1.0582. View

Hung-Chang Yao H, Whoriskey W, Capel B . Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. Genes Dev. 2002; 16(11):1433-40. PMC: 186321. DOI: 10.1101/gad.981202. View

Baker P, Johnston H, Abel M, Charlton H, OShaughnessy P . Differentiation of adult-type Leydig cells occurs in gonadotrophin-deficient mice. Reprod Biol Endocrinol. 2003; 1:4. PMC: 151561. DOI: 10.1186/1477-7827-1-4. View

Zhang F, Pakarainen T, Zhu F, Poutanen M, Huhtaniemi I . Molecular characterization of postnatal development of testicular steroidogenesis in luteinizing hormone receptor knockout mice. Endocrinology. 2003; 145(3):1453-63. DOI: 10.1210/en.2003-1049. View

Ge R, Dong Q, Sottas C, Chen H, Zirkin B, Hardy M . Gene expression in rat leydig cells during development from the progenitor to adult stage: a cluster analysis. Biol Reprod. 2005; 72(6):1405-15. DOI: 10.1095/biolreprod.104.037499. View

Ge R, Dong Q, Sottas C, Papadopoulos V, Zirkin B, Hardy M . In search of rat stem Leydig cells: identification, isolation, and lineage-specific development. Proc Natl Acad Sci U S A. 2006; 103(8):2719-24. PMC: 1413776. DOI: 10.1073/pnas.0507692103. View

Tang H, Brennan J, Karl J, Hamada Y, Raetzman L, Capel B . Notch signaling maintains Leydig progenitor cells in the mouse testis. Development. 2008; 135(22):3745-53. PMC: 3653410. DOI: 10.1242/dev.024786. View

Chen H, Ge R, Zirkin B . Leydig cells: From stem cells to aging. Mol Cell Endocrinol. 2009; 306(1-2):9-16. PMC: 2749461. DOI: 10.1016/j.mce.2009.01.023. View

Scott H, Mason J, Sharpe R . Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds. Endocr Rev. 2009; 30(7):883-925. DOI: 10.1210/er.2009-0016. View

10.

Griffin D, Ellis P, Dunmore B, Bauer J, Abel M, Affara N . Transcriptional profiling of luteinizing hormone receptor-deficient mice before and after testosterone treatment provides insight into the hormonal control of postnatal testicular development and Leydig cell differentiation. Biol Reprod. 2010; 82(6):1139-50. PMC: 2874499. DOI: 10.1095/biolreprod.109.082099. View

11.

Hardy M, Kelce W, Klinefelter G, EWING L . Differentiation of Leydig cell precursors in vitro: a role for androgen. Endocrinology. 1990; 127(1):488-90. DOI: 10.1210/endo-127-1-488. View

12.

Hardy M, Zirkin B, EWING L . Kinetic studies on the development of the adult population of Leydig cells in testes of the pubertal rat. Endocrinology. 1989; 124(2):762-70. DOI: 10.1210/endo-124-2-762. View

13.

Benton L, Shan L, Hardy M . Differentiation of adult Leydig cells. J Steroid Biochem Mol Biol. 1995; 53(1-6):61-8. DOI: 10.1016/0960-0760(95)00022-r. View

14.

Abney T, Zhai J . Gene expression of luteinizing hormone receptor and steroidogenic enzymes during Leydig cell development. J Mol Endocrinol. 1998; 20(1):119-27. DOI: 10.1677/jme.0.0200119. View