CCN Notch Signaling in Vascular Smooth Muscle Cells: Good or Bad?

Overview

Journal Arterioscler Thromb Vasc Biol

Date 2010 Mar 19

PMID 20237327

Citations 5

Authors

Jun-Ichi Abe

Chen Yan

Affiliations

Soon will be listed here.

Citing Articles

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Aneurysm severity is suppressed by deletion of CCN4.

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CCN3 and DLL1 co-regulate osteogenic differentiation of mouse embryonic fibroblasts in a Hey1-dependent manner.

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Protective role of the matricellular protein CCN3 in abdominal aortic aneurysm.

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References

Wu J, Lingrel J . KLF2 inhibits Jurkat T leukemia cell growth via upregulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1. Oncogene. 2004; 23(49):8088-96. DOI: 10.1038/sj.onc.1207996. View

Chen C, Lau L . Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol. 2008; 41(4):771-83. PMC: 2668982. DOI: 10.1016/j.biocel.2008.07.025. View

Dulic V, Kaufmann W, Wilson S, Tlsty T, Lees E, Harper J . p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell. 1994; 76(6):1013-23. DOI: 10.1016/0092-8674(94)90379-4. View

Li Y, Takeshita K, Liu P, Satoh M, Oyama N, Mukai Y . Smooth muscle Notch1 mediates neointimal formation after vascular injury. Circulation. 2009; 119(20):2686-92. PMC: 2744039. DOI: 10.1161/CIRCULATIONAHA.108.790485. View

Chen C, Chen N, Lau L . The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts. J Biol Chem. 2000; 276(13):10443-52. DOI: 10.1074/jbc.M008087200. View

Lagger G, Doetzlhofer A, Schuettengruber B, Haidweger E, Simboeck E, Tischler J . The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene. Mol Cell Biol. 2003; 23(8):2669-79. PMC: 152549. DOI: 10.1128/MCB.23.8.2669-2679.2003. View

Morrow D, Guha S, Sweeney C, Birney Y, Walshe T, OBrien C . Notch and vascular smooth muscle cell phenotype. Circ Res. 2008; 103(12):1370-82. DOI: 10.1161/CIRCRESAHA.108.187534. View

Sakata Y, Xiang F, Chen Z, Kiriyama Y, Kamei C, Simon D . Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro. Arterioscler Thromb Vasc Biol. 2004; 24(11):2069-74. DOI: 10.1161/01.ATV.0000143936.77094.a4. View

Funato N, Ohtani K, Ohyama K, Kuroda T, Nakamura M . Common regulation of growth arrest and differentiation of osteoblasts by helix-loop-helix factors. Mol Cell Biol. 2001; 21(21):7416-28. PMC: 99914. DOI: 10.1128/MCB.21.21.7416-7428.2001. View

10.

Holbourn K, Perbal B, Acharya K . Proteins on the catwalk: modelling the structural domains of the CCN family of proteins. J Cell Commun Signal. 2009; 3(1):25-41. PMC: 2686754. DOI: 10.1007/s12079-009-0048-4. View

11.

Dsouza B, Miyamoto A, Weinmaster G . The many facets of Notch ligands. Oncogene. 2008; 27(38):5148-67. PMC: 2791526. DOI: 10.1038/onc.2008.229. View

12.

Roy S, Tenniswood M . Site-specific acetylation of p53 directs selective transcription complex assembly. J Biol Chem. 2006; 282(7):4765-4771. DOI: 10.1074/jbc.M609588200. View

13.

Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M . The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway. J Biol Chem. 2002; 277(33):29399-405. DOI: 10.1074/jbc.M203727200. View

14.

Perbal B . CCN3: Doctor Jekyll and Mister Hyde. J Cell Commun Signal. 2008; 2(1-2):3-7. PMC: 2570013. DOI: 10.1007/s12079-008-0028-0. View

15.

Holbourn K, Acharya K, Perbal B . The CCN family of proteins: structure-function relationships. Trends Biochem Sci. 2008; 33(10):461-73. PMC: 2683937. DOI: 10.1016/j.tibs.2008.07.006. View

16.

Bray S . Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol. 2006; 7(9):678-89. DOI: 10.1038/nrm2009. View

17.

Matsumae H, Yoshida Y, Ono K, Togi K, Inoue K, Furukawa Y . CCN1 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model. Arterioscler Thromb Vasc Biol. 2008; 28(6):1077-83. DOI: 10.1161/ATVBAHA.108.162362. View

18.

Minamizato T, Sakamoto K, Liu T, Kokubo H, Katsube K, Perbal B . CCN3/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathways. Biochem Biophys Res Commun. 2007; 354(2):567-73. DOI: 10.1016/j.bbrc.2007.01.029. View

19.

Wang W, Prince C, Hu X, Pollman M . HRT1 modulates vascular smooth muscle cell proliferation and apoptosis. Biochem Biophys Res Commun. 2003; 308(3):596-601. DOI: 10.1016/s0006-291x(03)01453-0. View

20.

Perbal B, Martinerie C, Sainson R, Werner M, He B, Roizman B . The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling. Proc Natl Acad Sci U S A. 1999; 96(3):869-74. PMC: 15317. DOI: 10.1073/pnas.96.3.869. View