Maternal and Neonatal Outcomes Based on the Gestational Age of Midtrimester Preterm Premature Rupture of Membranes

Overview

Journal J Matern Fetal Neonatal Med

Publisher Informa Healthcare

Specialty Gynecology & Obstetrics

Date 2010 Mar 18

PMID 20233131

Citations 7

Authors

Aaron Deutsch

Elana Deutsch

Crystal Totten

Katheryne Downes

Laura Haubner

Victoria Belogolovkin

Affiliations

Soon will be listed here.

Abstract

Objectives: Determine neonatal and maternal outcomes based on the gestational age (GA) that midtrimester preterm premature rupture of membranes (mtPPROM) occurs.

Study Design: A retrospective chart review was conducted on pregnancies with mtPPROM between 180/7 and 236/7 weeks gestation from January 2000 to December 2007. Antenatal complications, maternal morbidity, and neonatal survival and morbidity were analysed by the specific GA of mtPPROM. Statistical analysis was performed using Chi-square, Fisher's Exact, and Kruskal-Wallis tests.

Results: A total of 105 patients met inclusion criteria. There was a trend for longer latency with earlier GA of mtPPROM (p=0.05). Neonatal survival to discharge was 26.6%, with an overall morbidity of 86%. Survival was significantly higher with mtPPROM at 22 0/7-23 6/7 weeks compared to 18 0/7-19 6/7 (p=0.01) and 20 0/7-21 6/7 weeks (p=0.01). There was no difference in neonatal morbidity based on the GA of mtPPROM.

Conclusions: While neonatal survival improves at later GAs of mtPPROM, morbidity continues to be high.

Citing Articles

Latency to delivery and incidence of adverse obstetric and perinatal outcomes in preterm premature rupture of membranes before 32 weeks.

Seravalli V, Colucci C, Di Cencio C, Morucchio A, Barsanti F, Di Tommaso M Arch Gynecol Obstet. 2025; .

PMID: 39928128 DOI: 10.1007/s00404-025-07970-3.

Maternal Outcomes Following Active vs. Expectant Management of Previable Preterm Pre-Labor Rupture of Membranes: A Meta-Analysis.

Sylvester M, Mintz G, Sisti G Children (Basel). 2023; 10(8).

PMID: 37628346 PMC: 10453507. DOI: 10.3390/children10081347.

A new rapid bedside test to diagnose and monitor intraamniotic inflammation in preterm PROM using transcervically collected fluid.

Oh K, Lee J, Romero R, Park H, Hong J, Yoon B Am J Obstet Gynecol. 2020; 223(3):423.e1-423.e15.

PMID: 32114081 PMC: 9521159. DOI: 10.1016/j.ajog.2020.02.037.

Preterm infant outcomes in relation to the gestational age of onset and duration of prelabour rupture of membranes: a retrospective cohort study.

Pharande P, Mohamed A, Bajuk B, Lui K, Bolisetty S BMJ Paediatr Open. 2018; 1(1):e000216.

PMID: 29637178 PMC: 5862203. DOI: 10.1136/bmjpo-2017-000216.

A new antibiotic regimen treats and prevents intra-amniotic inflammation/infection in patients with preterm PROM.

Lee J, Romero R, Kim S, Chaemsaithong P, Yoon B J Matern Fetal Neonatal Med. 2015; 29(17):2727-37.

PMID: 26441216 PMC: 5703065. DOI: 10.3109/14767058.2015.1103729.