Lack of Neo-sensitization to Pen a 1 in Patients Treated with Mite Sublingual Immunotherapy

Overview

Journal Clin Mol Allergy

Publisher Biomed Central

Specialty Allergy & Immunology

Date 2010 Mar 17

PMID 20230633

Citations 6

Authors

Renato E Rossi

Giorgio Monasterolo

Cristoforo Incorvaia

Philippe Moingeon

Franco Frati

Giovanni Passalacqua

Lucilla Rossi

Giorgio W Canonica

Affiliations

Soon will be listed here.

Abstract

Background: Some studies reported the possible induction of food allergy, caused by neo-sensitization to cross-reacting allergens, during immunotherapy with aeroallergens, while other studies ruled out such possibility.

Objectives: The aim of this study was to evaluate the development of neo-sensitization to Pen a 1 (tropomyosin) as well as the appearance of reactions after ingestion of foods containing tropomyosin as a consequence of sublingual mite immunization.

Materials And Methods: Specific IgE to Tropomyosin (rPen a 1) before and after mite sublingual immunotherapy in 134 subjects were measured. IgE-specific antibodies for mite extract and recombinant allergen Pen a 1 were evaluated using the immunoenzymatic CAP system (Phadia Diagnostics, Milan, Italy).

Results: All patients had rPen a 1 IgE negative results before and after mite SLIT and did not show positive shrimp extract skin reactivity and serological rPen a 1 IgE conversion after treatment. More important, no patient showed systemic reactions to crustacean ingestion.

Conclusions: Patients did not show neo-sensitization to tropomyosin, a component of the extract (namely mite group 10) administered. An assessment of a patient's possible pre-existing sensitisation to tropomyosin by skin test and/or specific IgE prior to start mite extract immunotherapy is recommended.

Trial Registration: This trial is registered in EudraCT, with the ID number of 2010-02035531.

Citing Articles

Dietary Habits in Patients with Chronic Spontaneous Urticaria: Evaluation of Food as Trigger of Symptoms Exacerbation.

Sanchez J, Sanchez A, Cardona R Dermatol Res Pract. 2018; 2018:6703052.

PMID: 30018635 PMC: 6029436. DOI: 10.1155/2018/6703052.

High rate of house dust mite sensitization in a shrimp allergic southern Ontario population.

Rosenfield L, Tsoulis M, Milio K, Schnittke M, Kim H Allergy Asthma Clin Immunol. 2017; 13:5.

PMID: 28115965 PMC: 5244585. DOI: 10.1186/s13223-017-0177-x.

Shellfish and House Dust Mite Allergies: Is the Link Tropomyosin?.

Wong L, Huang C, Lee B Allergy Asthma Immunol Res. 2016; 8(2):101-6.

PMID: 26739402 PMC: 4713872. DOI: 10.4168/aair.2016.8.2.101.

Cross-reactivity between aeroallergens and food allergens.

Popescu F World J Methodol. 2015; 5(2):31-50.

PMID: 26140270 PMC: 4482820. DOI: 10.5662/wjm.v5.i2.31.

Clinical and immunological changes of immunotherapy in patients with atopic dermatitis: randomized controlled trial.

Sanchez Caraballo J, Cardona Villa R ISRN Allergy. 2013; 2012:183983.

PMID: 23724240 PMC: 3658480. DOI: 10.5402/2012/183983.

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