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Exploratory Research on Bioactive Natural Products with a Focus on Biological Phenomena

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Specialties Biology
Science
Date 2010 Mar 16
PMID 20228620
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Abstract

The discovery of new basic compounds holds the key for advancing material sciences. We have focused on the identification and characterization of natural key compounds that control biologically and physiologically intriguing phenomena. The discovery of new bioactive molecules, facilitated by a deeper understanding of nature, should advance our knowledge of biological processes and lead to new strategies to treat disease. The structure and function of natural compounds are sometimes unexpectedly original. Based on our past experience and results, we have carried out research to find new directions for compound exploration by directly learning from dynamic biological phenomena in the field, and have succeeded in creating a new research field in biological molecular sciences.

References
1.
Moore R, Scheuer P . Palytoxin: a new marine toxin from a coelenterate. Science. 1971; 172(3982):495-8. DOI: 10.1126/science.172.3982.495. View

2.
Stocking E, Williams R . Chemistry and biology of biosynthetic Diels-Alder reactions. Angew Chem Int Ed Engl. 2003; 42(27):3078-115. DOI: 10.1002/anie.200200534. View

3.
Kita M, Nakamura Y, Okumura Y, Ohdachi S, Oba Y, Yoshikuni M . Blarina toxin, a mammalian lethal venom from the short-tailed shrew Blarina brevicauda: Isolation and characterization. Proc Natl Acad Sci U S A. 2004; 101(20):7542-7. PMC: 419642. DOI: 10.1073/pnas.0402517101. View

4.
Hao J, Matsuura F, Kishi Y, Kita M, Uemura D, Asai N . Stereochemistry of pteriatoxins A, B, and C. J Am Chem Soc. 2006; 128(24):7742-3. PMC: 2516745. DOI: 10.1021/ja061893j. View

5.
Ito K, Toyoda I, Higashiyama M, Uemura D, Sato M, Yoshimura S . Channel induction by palytoxin in yeast cells expressing Na+,K+-ATPase or its chimera with sarco/endoplasmic reticulum Ca2+-ATPase. FEBS Lett. 2003; 543(1-3):108-12. DOI: 10.1016/s0014-5793(03)00418-6. View