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Alcohol Drinking, Cigarette Smoking, and the Development of Squamous Cell Carcinoma of the Esophagus: Molecular Mechanisms of Carcinogenesis

Overview
Specialty Oncology
Date 2010 Mar 13
PMID 20224883
Citations 62
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Abstract

Esophageal cancer is the eighth most common incident cancer in the world and ranks sixth among all cancers in mortality. Esophageal cancers are classified into two histological types; esophageal squamous cell carcinoma (ESCC), and adenocarcinoma, and the incidences of these types show a striking variety of geographic distribution, possibly reflecting differences in exposure to specific environmental factors. Both alcohol consumption and cigarette smoking are major risk factors for the development of ESCC. Acetaldehyde is the most toxic ethanol metabolite in alcohol-associated carcinogenesis, while ethanol itself stimulates carcinogenesis by inhibiting DNA methylation and by interacting with retinoid metabolism. Cigarette smoke contains more than 60 carcinogens and there are strong links between some of these carcinogens and various smoking-induced cancers; these mechanisms are well established. Synergistic effects of cigarette smoking and alcohol consumption are also observed in carcinogenesis of the upper aerodigestive tract. Of note, intensive molecular biological studies have revealed the molecular mechanisms involved in the development of ESCC, including genetic and epigenetic alterations. However, a wide range of molecular changes is associated with ESCC, possibly because the esophagus is exposed to many kinds of carcinogens including alcohol and cigarette smoke, and it remains unclear which alterations are the most critical for esophageal carcinogenesis. This brief review summarizes the general mechanisms of alcohol- and smoking-induced carcinogenesis and then discusses the mechanisms of the development of ESCC, with special attention to alcohol consumption and cigarette smoking.

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References
1.
Baylin S . DNA methylation and gene silencing in cancer. Nat Clin Pract Oncol. 2005; 2 Suppl 1:S4-11. DOI: 10.1038/ncponc0354. View

2.
Jalas J, Hecht S, Murphy S . Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen. Chem Res Toxicol. 2005; 18(2):95-110. DOI: 10.1021/tx049847p. View

3.
Saeki H, Ohno S, Araki K, Egashira A, Kawaguchi H, Ikeda Y . Alcohol consumption and cigarette smoking in relation to high frequency of p53 protein accumulation in oesophageal squamous cell carcinoma in the Japanese. Br J Cancer. 2000; 82(11):1892-4. PMC: 2363236. DOI: 10.1054/bjoc.1999.1212. View

4.
Soma T, Kaganoi J, Kawabe A, Kondo K, Imamura M, Shimada Y . Nicotine induces the fragile histidine triad methylation in human esophageal squamous epithelial cells. Int J Cancer. 2006; 119(5):1023-7. DOI: 10.1002/ijc.21948. View

5.
Kozack R, Seo K, Jelinsky S, Loechler E . Toward an understanding of the role of DNA adduct conformation in defining mutagenic mechanism based on studies of the major adduct (formed at N(2)-dG) of the potent environmental carcinogen, benzo[a]pyrene. Mutat Res. 2000; 450(1-2):41-59. DOI: 10.1016/s0027-5107(00)00015-4. View