Treating Hypertensive Patients with Coronary Artery Disease: Renewed Interest in INVEST

Ried L, Tueth M, Handberg E, Kupfer S, Pepine C . A Study of Antihypertensive Drugs and Depressive Symptoms (SADD-Sx) in patients treated with a calcium antagonist versus an atenolol hypertension Treatment Strategy in the International Verapamil SR-Trandolapril Study (INVEST). Psychosom Med. 2005; 67(3):398-406. DOI: 10.1097/01.psy.0000160468.69451.7f. View

Dahlof B, Sever P, Poulter N, Wedel H, Beevers D, Caulfield M . Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm.... Lancet. 2005; 366(9489):895-906. DOI: 10.1016/S0140-6736(05)67185-1. View

Cooper-DeHoff R, Handberg E, Mancia G, Zhou Q, Champion A, Legler U . INVEST revisited: review of findings from the International Verapamil SR-Trandolapril Study. Expert Rev Cardiovasc Ther. 2009; 7(11):1329-40. PMC: 2800790. DOI: 10.1586/erc.09.102. View

Lichtman J, Bigger Jr J, Blumenthal J, Frasure-Smith N, Kaufmann P, Lesperance F . Depression and coronary heart disease: recommendations for screening, referral, and treatment: a science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology,.... Circulation. 2008; 118(17):1768-75. DOI: 10.1161/CIRCULATIONAHA.108.190769. View

. INVEST endorses Verapamil in hypertensives with CAD and highlights diabetes prevention. Cardiovasc J S Afr. 2003; 14(4):208-11. View