Persistently Elevated CKMB and Negative Troponin T in a Patient at Ischaemic Risk with Chest Pain
Overview
Overview
Journal
Cardiovasc J Afr
Specialty
Cardiology & Vascular Diseases
Date
2010 Mar 13
PMID
20224846
Citations
1
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Analytical interference in laboratory assays is not only unpredictable but also an underestimated problem. Not recognising these interferences can lead to misdiagnosis and mismanagement of patients. We present a case of a patient with chest pain and ischaemic risk factors with incongruent biochemical results. These results were discovered to be due to the presence of macro-creatine kinase (macro-CK) in vivo interfering with the CKMB activity assay.
Citing Articles
Kim S, Um T, Cho C, Jeon J Ann Lab Med. 2014; 34(5):405-7.
PMID: 25187898 PMC: 4151014. DOI: 10.3343/alm.2014.34.5.405.
References
1.
Wu A
. Cardiac troponin: friend of the cardiac physician, foe to the cardiac patient?. Circulation. 2006; 114(16):1673-5.
DOI: 10.1161/CIRCULATIONAHA.106.652123.
View
2.
Apple F, Jesse R, Newby L, Wu A, Christenson R
. National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: Analytical issues for biochemical markers of acute coronary syndromes. Circulation. 2007; 115(13):e352-5.
DOI: 10.1161/CIRCULATIONAHA.107.182881.
View
3.
Fahie-Wilson M, Burrows S, Lawson G, Gordon T, Wong W, Dasgupta B
. Prevalence of increased serum creatine kinase activity due to macro-creatine kinase and experience of screening programmes in district general hospitals. Ann Clin Biochem. 2007; 44(Pt 4):377-83.
DOI: 10.1258/000456307780945642.
View
4.
Remaley A, Wilding P
. Macroenzymes: biochemical characterization, clinical significance, and laboratory detection. Clin Chem. 1989; 35(12):2261-70.
View