Allergen-induced Airway Inflammation and Its Therapeutic Intervention

Overview

Journal Allergy Asthma Immunol Res

Date 2010 Mar 13

PMID 20224664

Citations 14

Authors

Paul M OByrne

Affiliations

Soon will be listed here.

Abstract

Allergen inhalation challenge has been useful for examining the mechanisms of allergen-induced airway inflammation and the associated physiological changes and for documenting the efficacy of drugs to treat asthma. Allergen inhalation by a sensitized subject results in acute bronchoconstriction, beginning within 15-30 min and lasting 1-3 hr, which can be followed by the development of a late asthmatic response. Individuals who develop both an early and late response after allergen have more marked increases in airway hyperresponsiveness, and greater increases in allergen-induced airway inflammation, particularly in airway eosinophils and basophils. All of the currently available and effective treatments for asthma modify some aspects of allergen-induced responses. These medications include short-acting and long-acting inhaled beta(2)-agonists, inhaled corticosteroids, cromones, methylxanthines, leukotriene inhibitors, and anti-IgE monoclonal antibody. In addition, allergen inhalation challenge has become a useful method which can, in a very limited number of patients, provide key information on the therapeutic potential of new drugs being developed to treat asthma.

Citing Articles

Usefulness of House Dust Mite Nasal Provocation Test in Asthma.

Choi I, Kim S, Won J, Park M Allergy Asthma Immunol Res. 2017; 9(2):152-157.

PMID: 28102060 PMC: 5266119. DOI: 10.4168/aair.2017.9.2.152.

Allergen inhalation challenge, refractoriness and the effects of ibuprofen.

Nomani S, Cockcroft D, Davis B Allergy Asthma Clin Immunol. 2016; 12:24.

PMID: 27222654 PMC: 4878003. DOI: 10.1186/s13223-016-0127-z.

A novel model of IgE-mediated passive pulmonary anaphylaxis in rats.

Wex E, Thaler E, Blum S, Lamb D PLoS One. 2014; 9(12):e116166.

PMID: 25541997 PMC: 4277472. DOI: 10.1371/journal.pone.0116166.

Adjustment of sensitisation and challenge protocols restores functional and inflammatory responses to ovalbumin in guinea-pigs.

Lowe A, Broadley K, Nials A, Ford W, Kidd E J Pharmacol Toxicol Methods. 2014; 72:85-93.

PMID: 25450500 PMC: 4370377. DOI: 10.1016/j.vascn.2014.10.007.

The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma.

Leaker B, Singh D, Ali F, Barnes P, OConnor B BMC Pulm Med. 2014; 14:166.

PMID: 25351474 PMC: 4228152. DOI: 10.1186/1471-2466-14-166.

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