How Important is the Phosphatase Activity of Sensor Kinases?

Overview

Journal Curr Opin Microbiol

Specialty Microbiology

Date 2010 Mar 13

PMID 20223700

Citations 33

Authors

Linda J Kenney

Affiliations

Soon will be listed here.

Abstract

In two-component signaling systems, phosphorylated response regulators (RRs) are often dephosphorylated by their partner kinases in order to control the in vivo concentration of phospho-RR (RR approximately P). This activity is easily demonstrated in vitro, but these experiments have typically used very high concentrations of the histidine kinase (HK) compared to the RR approximately P. Many two-component systems exhibit exquisite control over the ratio of HK to RR in vivo. The question thus arises as to whether the phosphatase activity of HKs is significant in vivo. This topic will be explored in the present review.

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