[Atypical Lipomatous Tumors of the Stomach. Clinical, Morphological and Molecular Findings]

Overview

Journal Pathologe

Specialty Pathology

Date 2010 Mar 12

PMID 20221763

Authors

C Kuhnen

T Mentzel

W Haarmann

U Schwegler

R Sciot

M Debiec-Rychter

Affiliations

Soon will be listed here.

Abstract

Two cases of primary gastric atypical lipomatous tumors (ALT) are presented. In case No.1, a 7x4x3 cm submucosal ALT (lipoma-like subtype) of the antrum/pyloric region in a 60-year-old woman was completely resected. Using interphase dual-color-FISH, MDM2- and CDK4 amplifications could be detected in distinguished amplicons. The patient was continuously free of disease after 56 months. In case No. 2, a 3.5 cm (in diameter) submucosal ALT (lipoma-like subtype) of the gastric body in a 56-year-old woman was completely resected. FISH revealed MDM2 amplification while the CDK4 gene remained in diploid copies. This patient was continuously free of disease after 36 months. The morphologic and molecular biological findings of this rare primary gastric mesenchymal tumor are discussed in comparison with the corresponding soft tissue lesions.

References

Shokouh-Amiri M, Hansen C, Moesgaard F . Liposarcoma of the stomach. A case report. Acta Chir Scand. 1986; 152:389-91. View

Seki K, Hasegawa T, Konegawa R, Hizawa K, Sano T . Primary liposarcoma of the stomach: a case report and a review of the literature. Jpn J Clin Oncol. 1998; 28(4):284-8. DOI: 10.1093/jjco/28.4.284. View

Philipps B, Lorken M, Manegold E, Kasperk R, Schumpelick V . [Primary liposarcoma of the stomach wall--a rare mesenchymal tumor]. Chirurg. 2000; 71(3):334-6. View

Kuhnen C, Mentzel T, Lehnhardt M, Homann H, Sciot R, Debiec-Rychter M . [Lipoma and atypical lipomatous tumor within the same neoplasia: Evidence for a continuous transition]. Pathologe. 2010; 31(2):129-34. DOI: 10.1007/s00292-009-1257-6. View

Ferrozzi F, Bova D, Garlaschi G . Gastric liposarcoma: CT appearance. Abdom Imaging. 1993; 18(3):232-3. DOI: 10.1007/BF00198110. View

Italiano A, Bianchini L, Keslair F, Bonnafous S, Cardot-Leccia N, Coindre J . HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon. Int J Cancer. 2008; 122(10):2233-41. DOI: 10.1002/ijc.23380. View

HOHF R, ENGEL K, CAPOS N . Liposarcoma of the stomach. Ann Surg. 1955; 142(6):1029-33. PMC: 1464952. DOI: 10.1097/00000658-195512000-00024. View

Mentzel T . [Lipomatous tumors of the skin and soft tissue. New entities and concepts]. Pathologe. 2001; 21(6):441-8. DOI: 10.1007/s002920000413. View

Italiano A, Bianchini L, Gjernes E, Keslair F, Ranchere-Vince D, Dumollard J . Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas. Clin Cancer Res. 2009; 15(18):5696-703. DOI: 10.1158/1078-0432.CCR-08-3185. View

10.

Debiec-Rychter M, Lasota J, Sarlomo-Rikala M, Kordek R, Miettinen M . Chromosomal aberrations in malignant gastrointestinal stromal tumors: correlation with c-KIT gene mutation. Cancer Genet Cytogenet. 2001; 128(1):24-30. DOI: 10.1016/s0165-4608(01)00395-8. View

11.

Costa e Silva N, Melo C, Naves E, Dias M . [Gastric liposarcoma: report of a case]. Rev Hosp Clin Fac Med Sao Paulo. 1992; 47(2):89-91. View

12.

Michiels A, Hubens G, Ruppert M, Balliu L, Vaneerdeweg W . Giant liposarcoma of the stomach involving the mediastinum. Acta Chir Belg. 2007; 107(4):468-71. DOI: 10.1080/00015458.2007.11680102. View

13.

Laky D, Stoica T . Gastric liposarcoma. A case report. Pathol Res Pract. 1986; 181(1):112-7. DOI: 10.1016/S0344-0338(86)80202-3. View

14.

Lopez-Negrete L, Luyando L, Sala J, Lopez C, Menendez de Llano R, Gomez J . Liposarcoma of the stomach. Abdom Imaging. 1997; 22(4):373-5. DOI: 10.1007/s002619900213. View

15.

Weaver J, Downs-Kelly E, Goldblum J, Turner S, Kulkarni S, Tubbs R . Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms. Mod Pathol. 2008; 21(8):943-9. DOI: 10.1038/modpathol.2008.84. View

16.

Tepetes K, Christodoulidis G, Spyridakis M, Nakou M, Koukoulis G, Hatzitheofilou K . Liposarcoma of the stomach: a rare case report. World J Gastroenterol. 2007; 13(30):4154-5. PMC: 4205325. DOI: 10.3748/wjg.v13.i30.4154. View

17.

Kuhnen C, Mentzel T, Sciot R, Lehnhardt M, Homann H, Debiec-Rychter M . Dedifferentiated liposarcoma with extensive lymphoid component. Pathol Res Pract. 2005; 201(4):347-53. DOI: 10.1016/j.prp.2005.01.009. View

18.

Mentzel T . Biological continuum of benign, atypical, and malignant mesenchymal neoplasms - does it exist?. J Pathol. 2000; 190(5):523-5. DOI: 10.1002/(SICI)1096-9896(200004)190:5<523::AID-PATH578>3.0.CO;2-#. View

19.

Orita K, Kokumai Y, Kawada K, Takagi S, Kawahara T . Liposarcoma of stomach: report of a case. Acta Med Okayama (1952). 1968; 22(3):167-73. View

20.

HAWKINS P, TERRELL G . LIPOSARCOMA OF THE STOMACH: A CASE REPORT. JAMA. 1965; 191:758-9. DOI: 10.1001/jama.1965.03080090072023. View