The Reproductive Outcome of Female Patients with Myotonic Dystrophy Type 1 (DM1) Undergoing PGD is Not Affected by the Size of the Expanded CTG Repeat Tract

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2010 Mar 12

PMID 20221684

Citations 5

Authors

Willem Verpoest

Sara Seneca

Marjan De Rademaeker

Karen Sermon

Martine De Rycke

Michel De Vos

Patrick Haentjens

Paul Devroey

Ingeborg Liebaers

Affiliations

Soon will be listed here.

Abstract

Purpose: This study aims to analyze the relationship between trinucleotide repeat length and reproductive outcome in a large cohort of DM1 patients undergoing ICSI and PGD.

Methods: Prospective cohort study. The effect of trinucleotide repeat length on reproductive outcome per patient was analyzed using bivariate analysis (T-test) and multivariate analysis using Kaplan-Meier and Cox regression analysis.

Results: Between 1995 and 2005, 205 cycles of ICSI and PGD were carried out for DM1 in 78 couples. The number of trinucleotide repeats does not have an influence on reproductive outcome when adjusted for age, BMI, basal FSH values, parity, infertility status and male or female affected. Cox regression analysis indicates that cumulative live birth rate is not influenced by the number of trinucleotide repeats. The only factor with a significant effect is age (p < 0.05).

Conclusion: There is no evidence of an effect of trinucleotide repeat length on reproductive outcome in patients undergoing ICSI and PGD.

Citing Articles

Ovarian response in preimplantation genetic testing for myotonic dystrophy type 1.

Sonigo C, Ranisavljevic N, Guigui M, Anahory T, Mayeur A, Moutou C J Assist Reprod Genet. 2024; 42(1):185-192.

PMID: 39709315 PMC: 11806121. DOI: 10.1007/s10815-024-03324-1.

Impact of prematurity and the CTG repeat length on outcomes in congenital myotonic dystrophy.

Saito Y, Matsumura K, Kageyama M, Kato Y, Ohta E, Sumi K BMC Res Notes. 2020; 13(1):350.

PMID: 32703309 PMC: 7379817. DOI: 10.1186/s13104-020-05186-z.

Preimplantation Genetic Diagnosis for Myotonic Dystrophy Type 1 and Analysis of the Effect of the Disease on the Reproductive Outcome of the Affected Female Patients.

Fernandez R, Lozano-Arana M, Sanchez B, Pecina A, Garcia-Lozano J, Borrego S Biomed Res Int. 2018; 2017:9165363.

PMID: 29349085 PMC: 5733891. DOI: 10.1155/2017/9165363.

Clinical characteristics of pregnancies complicated by congenital myotonic dystrophy.

Yee C, Choi S, Oh S, Ki C, Roh C, Kim J Obstet Gynecol Sci. 2017; 60(4):323-328.

PMID: 28791262 PMC: 5547078. DOI: 10.5468/ogs.2017.60.4.323.

Muscle wasting in myotonic dystrophies: a model of premature aging.

Mateos-Aierdi A, Goicoechea M, Aiastui A, Fernandez-Torron R, Garcia-Puga M, Matheu A Front Aging Neurosci. 2015; 7:125.

PMID: 26217220 PMC: 4496580. DOI: 10.3389/fnagi.2015.00125.

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