Hormesis Can and Does Work in Humans

Overview

Journal Dose Response

Publisher Sage Publications

Date 2010 Mar 12

PMID 20221290

Citations 24

Authors

Suresh I S Rattan

Dino Demirovic

Affiliations

Soon will be listed here.

Abstract

If we accept the validity of the general concept of physiological hormesis as being the phenomenon of achieving health beneficial effects by exposure to mild stress, then hormesis is being applied already and successfully to humans. The evidence for this is the well-demonstrated health benefits of regular and moderate exercise. Mild stress-induced activation of one or more intracellular pathways of stress response are central to this. Experimental studies performed on human cells in culture exposed to mild heat shock and other stresses provide biochemical and molecular evidence in support of the application of hormesis to human systems. Although several issues remain to be resolved by more research with respect to the extent and duration of hormetic exposure, making use of the cellular stress response pathways can facilitate discovering novel hormetins for human applications.

Citing Articles

GDF15/MIC-1: a stress-induced immunosuppressive factor which promotes the aging process.

Salminen A Biogerontology. 2024; 26(1):19.

PMID: 39643709 PMC: 11624233. DOI: 10.1007/s10522-024-10164-0.

Extracellular Matrix Dynamics as an Emerging yet Understudied Hallmark of Aging and Longevity.

Statzer C, Park J, Ewald C Aging Dis. 2023; 14(3):670-693.

PMID: 37191434 PMC: 10187690. DOI: 10.14336/AD.2022.1116.

Novel Insights on Ferroptosis Modulation as Potential Strategy for Cancer Treatment: When Nature Kills.

Consoli V, Fallica A, Sorrenti V, Pittala V, Vanella L Antioxid Redox Signal. 2023; 40(1-3):40-85.

PMID: 37132605 PMC: 10824235. DOI: 10.1089/ars.2022.0179.

Lack of peroxisomal catalase affects heat shock response in .

Musa M, Dionisio P, Casqueiro R, Milosevic I, Raimundo N, Krisko A Life Sci Alliance. 2022; 6(1).

PMID: 36347545 PMC: 9644420. DOI: 10.26508/lsa.202201737.

A collective analysis of lifespan-extending compounds in diverse model organisms, and of species whose lifespan can be extended the most by the application of compounds.

Berkel C, Cacan E Biogerontology. 2021; 22(6):639-653.

PMID: 34687363 DOI: 10.1007/s10522-021-09941-y.

References

Goto S, Naito H, Kaneko T, Young Chung H, Radak Z . Hormetic effects of regular exercise in aging: correlation with oxidative stress. Appl Physiol Nutr Metab. 2007; 32(5):948-53. DOI: 10.1139/H07-092. View

Rattan S . Theories of biological aging: genes, proteins, and free radicals. Free Radic Res. 2006; 40(12):1230-8. DOI: 10.1080/10715760600911303. View

Rattan S . Increased molecular damage and heterogeneity as the basis of aging. Biol Chem. 2008; 389(3):267-72. DOI: 10.1515/BC.2008.030. View

Liberek K, Lewandowska A, Zietkiewicz S . Chaperones in control of protein disaggregation. EMBO J. 2008; 27(2):328-35. PMC: 2234349. DOI: 10.1038/sj.emboj.7601970. View

Perez F, Zhou X, Morisaki J, Jurivich D . Electromagnetic field therapy delays cellular senescence and death by enhancement of the heat shock response. Exp Gerontol. 2008; 43(4):307-16. DOI: 10.1016/j.exger.2008.01.004. View

Goon J, Noor Aini A, Musalmah M, Yasmin Anum M, Wan Nazaimoon W, Wan Ngah W . Effect of Tai Chi exercise on DNA damage, antioxidant enzymes, and oxidative stress in middle-age adults. J Phys Act Health. 2009; 6(1):43-54. DOI: 10.1123/jpah.6.1.43. View

Rattan S . Hormesis in aging. Ageing Res Rev. 2007; 7(1):63-78. DOI: 10.1016/j.arr.2007.03.002. View

Medzhitov R . Origin and physiological roles of inflammation. Nature. 2008; 454(7203):428-35. DOI: 10.1038/nature07201. View

Longo V . Linking sirtuins, IGF-I signaling, and starvation. Exp Gerontol. 2008; 44(1-2):70-4. DOI: 10.1016/j.exger.2008.06.005. View

10.

Radak Z, Chung H, Koltai E, Taylor A, Goto S . Exercise, oxidative stress and hormesis. Ageing Res Rev. 2007; 7(1):34-42. DOI: 10.1016/j.arr.2007.04.004. View

11.

Rattan S, Fernandes R, Demirovic D, Dymek B, Lima C . Heat stress and hormetin-induced hormesis in human cells: effects on aging, wound healing, angiogenesis, and differentiation. Dose Response. 2009; 7(1):90-103. PMC: 2664638. DOI: 10.2203/dose-response.08-014.Rattan. View

12.

Hakem R . DNA-damage repair; the good, the bad, and the ugly. EMBO J. 2008; 27(4):589-605. PMC: 2262034. DOI: 10.1038/emboj.2008.15. View

13.

Fisher-Wellman K, Bloomer R . Acute exercise and oxidative stress: a 30 year history. Dyn Med. 2009; 8:1. PMC: 2642810. DOI: 10.1186/1476-5918-8-1. View

14.

Banhegyi G, Baumeister P, Benedetti A, Dong D, Fu Y, Lee A . Endoplasmic reticulum stress. Ann N Y Acad Sci. 2007; 1113:58-71. DOI: 10.1196/annals.1391.007. View

15.

Holliday R . A re-examination of the effects of ionizing radiation on lifespan and transformation of human diploid fibroblasts. Mutat Res. 1991; 256(2-6):295-302. DOI: 10.1016/0921-8734(91)90020-c. View

16.

Landi F, Russo A, Cesari M, Pahor M, Liperoti R, Danese P . Walking one hour or more per day prevented mortality among older persons: results from ilSIRENTE study. Prev Med. 2008; 47(4):422-6. DOI: 10.1016/j.ypmed.2008.06.020. View

17.

Bains W . Truly personalised medicine: self-experimentation in medical discovery. Med Hypotheses. 2007; 70(4):714-8. DOI: 10.1016/j.mehy.2007.08.018. View

18.

Verbeke P, Fonager J, Clark B, Rattan S . Heat shock response and ageing: mechanisms and applications. Cell Biol Int. 2001; 25(9):845-57. DOI: 10.1006/cbir.2001.0789. View

19.

Yates L, Djousse L, Kurth T, Buring J, Gaziano J . Exceptional longevity in men: modifiable factors associated with survival and function to age 90 years. Arch Intern Med. 2008; 168(3):284-90. DOI: 10.1001/archinternmed.2007.77. View

20.

Yoshida H . ER stress and diseases. FEBS J. 2007; 274(3):630-58. DOI: 10.1111/j.1742-4658.2007.05639.x. View