Targeting Early Infection to Prevent HIV-1 Mucosal Transmission

Overview

Journal Nature

Specialty Science

Date 2010 Mar 12

PMID 20220840

Citations 337

Authors

Ashley T Haase

Affiliations

Soon will be listed here.

Abstract

Measures to prevent sexual mucosal transmission of human immunodeficiency virus (HIV)-1 are urgently needed to curb the growth of the acquired immunodeficiency syndrome (AIDS) pandemic and ultimately bring it to an end. Studies in animal models and acute HIV-1 infection reviewed here reveal potential viral vulnerabilities at the mucosal portal of entry in the earliest stages of infection that might be most effectively targeted by vaccines and microbicides, thereby preventing acquisition and averting systemic infection, CD4 T-cell depletion and pathologies that otherwise rapidly ensue.

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