First Case of Human "Candidatus Neoehrlichia Mikurensis" Infection in a Febrile Patient with Chronic Lymphocytic Leukemia

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2010 Mar 12

PMID 20220155

Citations 80

Authors

Christina Welinder-Olsson

Eva Kjellin

Krista Vaht

Stefan Jacobsson

Christine Wenneras

Affiliations

Soon will be listed here.

Abstract

An immunocompromised patient presented with febrile episodes, an erysipelas-like rash, and thromboembolic complications. Amplification of 16S rRNA gene sequences from blood and sequence analysis revealed "Candidatus Neoehrlichia mikurensis." We report the first case of human disease caused by "Ca. Neoehrlichia mikurensis."

Citing Articles

Ten years of detecting Neoehrlichia mikurensis infections in Sweden: demographic, clinical and inflammatory parameters.

Wenneras C, Wass L, Bergstrom B, Grankvist A, Lingblom C Eur J Clin Microbiol Infect Dis. 2024; 43(11):2083-2092.

PMID: 39136831 PMC: 11535080. DOI: 10.1007/s10096-024-04909-5.

Detection and phylogenetic classification of in rodents from the region of Liupan Mountain, China.

Wang X, Pang B, Kou Z, Zhao J, Yan Y, Chen T Front Microbiol. 2024; 15:1409593.

PMID: 39027101 PMC: 11255843. DOI: 10.3389/fmicb.2024.1409593.

Ticks and Tick-Borne Pathogens Circulating in Peri-Domestic Areas in Mainland Portugal.

Moerbeck L, Parreira R, Szczotko M, Seixas G, Velez R, Dmitryjuk M Microorganisms. 2024; 12(5).

PMID: 38792834 PMC: 11123758. DOI: 10.3390/microorganisms12051006.

Tick-Borne Bacterial Diseases in Europe: Threats to public health.

Pustijanac E, Bursic M, Millotti G, Paliaga P, Ivesa N, Cvek M Eur J Clin Microbiol Infect Dis. 2024; 43(7):1261-1295.

PMID: 38676855 DOI: 10.1007/s10096-024-04836-5.

is uncommon in rheumatological patients receiving tumour necrosis factor inhibitors and in blood donors: a retrospective cohort study.

Gynthersen R, Orbaek M, Hogdall E, Glintborg B, Ostrowski S, Harritshoj L RMD Open. 2024; 10(1).

PMID: 38176737 PMC: 10773428. DOI: 10.1136/rmdopen-2023-003660.

References

Dumler J, Trigiani E, Bakken J, Aguero-Rosenfeld M, Wormser G . Serum cytokine responses during acute human granulocytic ehrlichiosis. Clin Diagn Lab Immunol. 2000; 7(1):6-8. PMC: 95813. DOI: 10.1128/CDLI.7.1.6-8.2000. View

Arav-Boger R, Knepp J, WALLS J, Dumler J . Human monocytic ehrlichiosis in a child with leukemia. Pediatr Infect Dis J. 2000; 19(2):173-5. DOI: 10.1097/00006454-200002000-00023. View

Klein M, Hu S, Chao C, Goodman J . The agent of human granulocytic ehrlichiosis induces the production of myelosuppressing chemokines without induction of proinflammatory cytokines. J Infect Dis. 2000; 182(1):200-5. DOI: 10.1086/315641. View

Tan H, Dumler J, Maley W, Klein A, Burdick J, Poordad F . Human monocytic ehrlichiosis: an emerging pathogen in transplantation. Transplantation. 2001; 71(11):1678-80. DOI: 10.1097/00007890-200106150-00030. View

Paddock C, Folk S, Shore G, Machado L, Huycke M, Slater L . Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in persons coinfected with human immunodeficiency virus. Clin Infect Dis. 2001; 33(9):1586-94. DOI: 10.1086/323981. View

Blanco J, Oteo J . Human granulocytic ehrlichiosis in Europe. Clin Microbiol Infect. 2003; 8(12):763-72. DOI: 10.1046/j.1469-0691.2002.00557.x. View

Skovbjerg S, Welinder-Olsson C, Kondori N, Kjellin E, Nowrouzian F, Wold A . Optimization of the detection of microbes in blood from immunocompromised patients with haematological malignancies. Clin Microbiol Infect. 2009; 15(7):680-3. DOI: 10.1111/j.1469-0691.2009.02796.x. View

Kawahara M, Rikihisa Y, Isogai E, Takahashi M, Misumi H, Suto C . Ultrastructure and phylogenetic analysis of 'Candidatus Neoehrlichia mikurensis' in the family Anaplasmataceae, isolated from wild rats and found in Ixodes ovatus ticks. Int J Syst Evol Microbiol. 2004; 54(Pt 5):1837-1843. DOI: 10.1099/ijs.0.63260-0. View

Barnewall R, Rikihisa Y . Abrogation of gamma interferon-induced inhibition of Ehrlichia chaffeensis infection in human monocytes with iron-transferrin. Infect Immun. 1994; 62(11):4804-10. PMC: 303190. DOI: 10.1128/iai.62.11.4804-4810.1994. View

10.

Bakken J, Dumler J . Clinical diagnosis and treatment of human granulocytotropic anaplasmosis. Ann N Y Acad Sci. 2006; 1078:236-47. DOI: 10.1196/annals.1374.042. View

11.

Tabara K, Arai S, Kawabuchi T, Itagaki A, Ishihara C, Satoh H . Molecular survey of Babesia microti, Ehrlichia species and Candidatus neoehrlichia mikurensis in wild rodents from Shimane Prefecture, Japan. Microbiol Immunol. 2007; 51(4):359-67. DOI: 10.1111/j.1348-0421.2007.tb03923.x. View

12.

Dumler J, Madigan J, Pusterla N, Bakken J . Ehrlichioses in humans: epidemiology, clinical presentation, diagnosis, and treatment. Clin Infect Dis. 2007; 45 Suppl 1:S45-51. DOI: 10.1086/518146. View

13.

van Overbeek L, Gassner F, van der Plas C, Kastelein P, Nunes-da Rocha U, Takken W . Diversity of Ixodes ricinus tick-associated bacterial communities from different forests. FEMS Microbiol Ecol. 2008; 66(1):72-84. DOI: 10.1111/j.1574-6941.2008.00468.x. View

14.

Lin M, Rikihisa Y . Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival. Infect Immun. 2003; 71(9):5324-31. PMC: 187327. DOI: 10.1128/IAI.71.9.5324-5331.2003. View