Substitution of Corticosteroid with Everolimus After Lung Transplantation: a Pediatric Case Report

Overview

Journal Pharm World Sci

Publisher Springer

Specialties Pharmacology
Pharmacy

Date 2010 Mar 11

PMID 20217477

Citations 5

Authors

Thibaut Caruba

Vanida Brunie

Veronique Bousseau

Romain Guillemain

Patrice Prognon

Dominique Begue

Brigitte Sabatier

Affiliations

Soon will be listed here.

Abstract

We report the case of a 12 year-old lung transplant recipient, in whom compressive epidural lipomatosis secondary to corticosteroid prompted us to replace prednisone with everolimus. Discontinuing corticosteroid treatment after lung transplantation is associated with a risk of graft rejection despite concomitant immunosuppressive therapy with tacrolimus and mycophenolate mofetil. During a follow-up of 18 months with everolimus instead of prednisone, we did not observe graft rejection. In parallel, all symptoms related to epidural compression disappeared within a month.

Citing Articles

Could Spinal Epidural Lipomatosis Be the Hallmark of Metabolic Syndrome on the Spine? A Literature Review with Emphasis on Etiology.

DAgostino V, Petrera M, Tedesco G, Pipola V, Ponti F, Spinnato P Diagnostics (Basel). 2023; 13(2).

PMID: 36673132 PMC: 9858169. DOI: 10.3390/diagnostics13020322.

Lipomatosis of spinal epidural space, peritoneum, and renal sinus: a rare complication of long-term steroid therapy in a child with nephrotic syndrome.

Dawman L, Bhattacharya D, Sharawat I, Indla R, Bhatia A, Tiewsoh K Childs Nerv Syst. 2019; 35(8):1401-1405.

PMID: 30941508 DOI: 10.1007/s00381-019-04141-z.

Management of idiopathic spinal epidural lipomatosis: a case report and review of the literature.

Papastefan S, Bhimani A, Denyer S, Khan S, Esfahani D, Nikas D Childs Nerv Syst. 2017; 34(4):757-763.

PMID: 29273822 DOI: 10.1007/s00381-017-3706-5.

[Spinal epidural lipomatosis].

Artner J, Leucht F, Cakir B, Reichel H, Lattig F Orthopade. 2012; 41(11):889-93.

PMID: 22772944 DOI: 10.1007/s00132-012-1966-z.

Corticosteroid-induced spinal epidural lipomatosis in the pediatric age group: report of a new case and updated analysis of the literature.

Moller J, Cron R, Young D, Girschick H, Levy D, Sherry D Pediatr Rheumatol Online J. 2011; 9(1):5.

PMID: 21284882 PMC: 3041993. DOI: 10.1186/1546-0096-9-5.

References

Borro J, Sole A, de la Torre M, Pastor A, Tarazona V . Steroid withdrawal in lung transplant recipients. Transplant Proc. 2006; 37(9):3991-3. DOI: 10.1016/j.transproceed.2005.09.190. View

Snell G, Valentine V, Vitulo P, Glanville A, McGiffin D, Loyd J . Everolimus versus azathioprine in maintenance lung transplant recipients: an international, randomized, double-blind clinical trial. Am J Transplant. 2006; 6(1):169-77. DOI: 10.1111/j.1600-6143.2005.01134.x. View

Koch M . Everolimus in liver and lung transplantation. Drugs Today (Barc). 2009; 45(1):11-20. DOI: 10.1358/dot.2009.45.1.1313982. View

Fieguth H, Simon A, Scherer M, Klesius A, Wiedenmann D . Immunosuppressive regimen in lung transplantation: initial intravenous mycophenolate mofetil and cyclosporine avoid cytolytic induction and allow for rapid steroid tapering. Transplant Proc. 2002; 34(5):1879-80. DOI: 10.1016/s0041-1345(02)03106-8. View

Faro A, Mallory G, Visner G, Elidemir O, Mogayzel Jr P, Danziger-Isakov L . American Society of Transplantation executive summary on pediatric lung transplantation. Am J Transplant. 2006; 7(2):285-92. DOI: 10.1111/j.1600-6143.2006.01612.x. View