» Articles » PMID: 20216212

GATA Factor Switching During Erythroid Differentiation

Overview
Specialty Hematology
Date 2010 Mar 11
PMID 20216212
Citations 52
Authors
Affiliations
Soon will be listed here.
Abstract

Purpose Of Review: Efforts have been made to understand how erythroid differentiation is regulated, and recent discoveries have clarified that lineage-specific transcription factor networks are essential for proper differentiation of erythroid cells. The transcription factors GATA1 and GATA2 are involved in such networks that regulate erythroid gene expression. Importantly, expression of Gata1 and Gata2 genes is also under the control of such regulatory networks. The present review is focused on the mechanism of Gata1 and Gata2 gene regulation during erythropoiesis and the physiological significance of their dynamic regulation.

Recent Findings: Gata1 and Gata2 genes are regulated by multiple transcription factors, including their own products GATA1 and GATA2. GATA1 and GATA2 recognize specific regulatory GATA motifs, and their expression levels change dynamically during erythroid differentiation, leading to diversified gene expression during erythropoiesis.

Summary: Strict regulations of the Gata1 and Gata2 genes are critical for proper lineage commitment and development of erythroid cells. It has been shown in transgenic mouse analyses that cis-acting GATA binding motifs are critical for the expression of Gata1 and Gata2 genes. Furthermore, expression of Gata1 and Gata2 genes along with a set of erythroid genes appeared to be regulated by GATA factor switching.

Citing Articles

A Review of Key Regulators of Steady-State and Ineffective Erythropoiesis.

Tichil I, Mitre I, Zdrenghea M, Bojan A, Tomuleasa C, Cenariu D J Clin Med. 2024; 13(9).

PMID: 38731114 PMC: 11084473. DOI: 10.3390/jcm13092585.


The role of GATA switch in benzene metabolite hydroquinone inhibiting erythroid differentiation in K562 cells.

Yu C, Yang S, Zhang Y, Rong L, Yi Z Arch Toxicol. 2023; 97(8):2169-2181.

PMID: 37329354 DOI: 10.1007/s00204-023-03541-0.


WhichTF is functionally important in your open chromatin data?.

Tanigawa Y, Dyer E, Bejerano G PLoS Comput Biol. 2022; 18(8):e1010378.

PMID: 36040971 PMC: 9426921. DOI: 10.1371/journal.pcbi.1010378.


Heterozygous variants in GATA2 contribute to DCML deficiency in mice by disrupting tandem protein binding.

Hasegawa A, Hayasaka Y, Morita M, Takenaka Y, Hosaka Y, Hirano I Commun Biol. 2022; 5(1):376.

PMID: 35440757 PMC: 9018821. DOI: 10.1038/s42003-022-03316-w.


A robust method for designing multistable systems by embedding bistable subsystems.

Wu S, Zhou T, Tian T NPJ Syst Biol Appl. 2022; 8(1):10.

PMID: 35338169 PMC: 8956579. DOI: 10.1038/s41540-022-00220-1.