Severe Intellectual Disability Does Not Preclude Renal Transplantation

Overview

Journal Nephrol Dial Transplant

Publisher Oxford University Press

Specialties General Surgery
Nephrology

Date 2010 Mar 11

PMID 20215391

Citations 10

Authors

Nelson Z Galante

Gustavo A Dib

Jose O Medina-Pestana

Affiliations

Soon will be listed here.

Abstract

Background: Intellectual disability (ID) in patients with chronic kidney disease is a relative contraindication for kidney transplantation.

Methods: We analysed a retrospective cohort of 16 recipients of kidney transplantation with ID and 83 controls.

Results: Graft survival at 5 years was similar between patients (81.2%) and controls (80.2%), P = 0.9. Patient survival at 5 years was lower among patients (81.2% versus 94.4%, P < 0.05). Patients had more infection episodes, but no risk factors were identified.

Conclusion: Although recipients with ID have lower long-term patient survival, the equivalent graft survival rates support the indication of renal transplantation in such disability.

Citing Articles

Case series of kidney transplantation in two pediatric recipients with rare genetic diseases and intellectual disability.

Mata M, Tabbara M, Alvarez A, Chandar J, Defreitas M, Ciancio G BMC Pediatr. 2024; 24(1):823.

PMID: 39696129 PMC: 11657740. DOI: 10.1186/s12887-024-05304-x.

Outcome of Solid Organ Transplantation in Patients With Intellectual Disability: A Systematic Literature Review.

de Rover I, Orlandini L, Murad S, Polak W, Hartley J, Sharif K Transpl Int. 2024; 37:11872.

PMID: 39483515 PMC: 11524806. DOI: 10.3389/ti.2024.11872.

Pretransplant Cognitive Function and Kidney Transplant Outcomes: A Prospective Cohort Study.

Gupta A, Grasing M, Young K, Montgomery R, Murillo D, Cibrik D Kidney Med. 2024; 6(9):100872.

PMID: 39206246 PMC: 11350261. DOI: 10.1016/j.xkme.2024.100872.

Disparities in treatment and outcome of kidney replacement therapy in children with comorbidities: an ESPN/ERA Registry study.

Schild R, Dupont S, Harambat J, Vidal E, Balat A, Bereczki C Clin Kidney J. 2023; 16(4):745-755.

PMID: 37007701 PMC: 10061422. DOI: 10.1093/ckj/sfad008.

Renal Replacement Therapy in children with severe developmental disability: guiding questions for decision-making.

Willem L, Knops N, Mekahli D, Cochat P, Edefonti A, Verrina E Eur J Pediatr. 2018; 177(12):1735-1743.

PMID: 30194525 DOI: 10.1007/s00431-018-3238-3.