Procalcitonin As a Prognostic Marker in Patients with Acute Myocardial Infarction

Overview

Journal Biomarkers

Specialty Biochemistry

Date 2010 Mar 11

PMID 20214413

Citations 11

Authors

Dominic Kelly

Sohail Q Khan

Onkar Dhillon

Paulene Quinn

Joachim Struck

Iain B Squire

Joan E Davies

Leong L Ng

Affiliations

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Abstract

Background: Procalcitonin is involved in the inflammatory response and is associated with adverse prognosis in certain conditions.

Aims: To investigate the association between procalcitonin and major adverse cardiac events (MACE), left ventricular (LV) function and remodelling following acute myocardial infarction (AMI).

Methods: Plasma procalcitonin was measured in 977 patients with AMI. Subjects were followed for MACE (median 671 days). A subgroup underwent echocardiography at discharge and follow-up LV function and volume assessment.

Results: Procalcitonin was associated with MACE on uni- and multivariable analysis. Kaplan-Meier assessment revealed an adverse outcome in subjects with procalcitonin above the median. Procalcitonin was related to markers of LV dysfunction and remodelling.

Conclusion: Procalcitonin is associated with MACE, LV dysfunction and remodelling post-AMI.

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