Gastrin-releasing Peptide Receptor Content in Human Glioma and Normal Brain

Overview

Journal Brain Res Bull

Specialty Neurology

Date 2010 Mar 10

PMID 20211708

Citations 13

Authors

Debora Gazzana Flores

Luise Meurer

Augusto Frantz Uberti

Bruno R Macedo

Guido Lenz

Algemir Lunardi Brunetto

Gilberto Schwartsmann

Rafael Roesler

Affiliations

Soon will be listed here.

Abstract

The gastrin-releasing peptide receptor (GRPR) has been put forward as a therapeutic target in brain tumors. Here we evaluated GRPR presence in glioma specimens from patients as well as in normal human brain samples. Sections of paraffin-embedded brain tumors and non-neoplastic control brain tissue were analyzed with immunohistochemistry for GRPR content. Digital image analysis revealed that 100% of glioma samples were GRPR-positive, with a mean index of 4972 pixels. In normal brain tissue, GRPR was detected in neurons, but not glial cells. This study is the first to confirm the presence of GRPR in human glioma specimens and normal human neurons.

Citing Articles

Dual-Labeled Small Peptides in Cancer Imaging and Fluorescence-Guided Surgery: Progress and Future Perspectives.

Minges P, Eder M, Eder A Pharmaceuticals (Basel). 2025; 18(2).

PMID: 40005958 PMC: 11858487. DOI: 10.3390/ph18020143.

Ga-NOTA-RM26 PET/CT in the evaluation of glioma: a pilot prospective study.

Li Y, Wang R, Chen J, Zhu Z, Wang Y, Ma W EJNMMI Res. 2025; 15(1):6.

PMID: 39821814 PMC: 11748694. DOI: 10.1186/s13550-025-01198-7.

Targeted radionuclide therapy for gliomas: Emerging clinical trial landscape.

Weller M, Albert N, Galldiks N, Bink A, Preusser M, Sulman E Neuro Oncol. 2024; 26(Supplement_9):S208-S214.

PMID: 39107236 PMC: 11631073. DOI: 10.1093/neuonc/noae125.

Glioma and Peptidergic Systems: Oncogenic and Anticancer Peptides.

Sanchez M, Mangas A, Covenas R Int J Mol Sci. 2024; 25(14).

PMID: 39063232 PMC: 11277022. DOI: 10.3390/ijms25147990.

Lower-grade gliomas surgery guided by GRPR-targeting PET/NIR dual-modality image probe: a prospective and single-arm clinical trial.

Chen L, Zhang J, Chi C, Che W, Dong G, Wang J Theranostics. 2024; 14(2):819-829.

PMID: 38169486 PMC: 10758047. DOI: 10.7150/thno.91554.