Studies on Novel D-ring Substituted Steroidal Pyrazolines As Potential Anticancer Agents

Overview

Journal Steroids

Publisher Elsevier

Specialty Biochemistry

Date 2010 Mar 9

PMID 20206644

Citations 16

Authors

Abid H Banday

Bilal P Mir

Imtiyaz H Lone

K A Suri

H M Sampath Kumar

Affiliations

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Abstract

An efficient and facile synthesis of 17-pyrazolinyl derivatives of pregnenolone and their evaluation as potential anticancer agents against various human cancer cell lines are reported. The scheme involves the transformation of the starting pregnenolone acetate into pregnenolone, conversion of pregnenolone to the corresponding benzylidine derivatives and finally the conversion of this derivative to the stable steroidal 17-pyrazoline. Various compounds 4b, 4c, 4e, 4f, 4h and 4j showed significant cytotoxic activity especially against HT-29, HCT-15, 502713 cell lines.

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