Inflammatory Bowel Disease in the Dog: Differences and Similarities with Humans

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2010 Mar 6

PMID 20205273

Citations 62

Authors

Matteo Cerquetella

Andrea Spaterna

Fulvio Laus

Beniamino Tesei

Giacomo Rossi

Elisabetta Antonelli

Vincenzo Villanacci

Gabrio Bassotti

Affiliations

Soon will be listed here.

Abstract

Inflammatory bowel diseases (IBD) represent important chronic conditions affecting the gastrointestinal tract in man. However, similar disorders are found in several animal species and the IBD affecting dogs are particularly important. These are encompassed by an umbrella of probably several different entities with common symptoms, some of which seem to share striking similarities with human conditions. This review will focus on the actual knowledge of IBD in dogs, and attempt to identify differences and similarities with human IBD conditions.

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References

German A, Bland P, Hall E, Day M . Expression of major histocompatibility complex class II antigens in the canine intestine. Vet Immunol Immunopathol. 1998; 61(2-4):171-80. DOI: 10.1016/s0165-2427(97)00144-x. View

Stange E, Travis S, Vermeire S, Beglinger C, Kupcinkas L, Geboes K . European evidence based consensus on the diagnosis and management of Crohn's disease: definitions and diagnosis. Gut. 2006; 55 Suppl 1:i1-15. PMC: 1859998. DOI: 10.1136/gut.2005.081950a. View

Ostanin D, Bao J, Koboziev I, Gray L, Robinson-Jackson S, Kosloski-Davidson M . T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade. Am J Physiol Gastrointest Liver Physiol. 2008; 296(2):G135-46. PMC: 2643911. DOI: 10.1152/ajpgi.90462.2008. View

Andoh A, Benno Y, Kanauchi O, Fujiyama Y . Recent advances in molecular approaches to gut microbiota in inflammatory bowel disease. Curr Pharm Des. 2009; 15(18):2066-73. DOI: 10.2174/138161209788489186. View

Atreya I, Atreya R, Neurath M . NF-kappaB in inflammatory bowel disease. J Intern Med. 2008; 263(6):591-6. DOI: 10.1111/j.1365-2796.2008.01953.x. View

Loftus Jr E . Clinical perspectives in Crohn's disease. Objective measures of disease activity: alternatives to symptom indices. Rev Gastroenterol Disord. 2007; 7 Suppl 2:S8-S16. View

Ishihara S, Aziz M, Yuki T, Kazumori H, Kinoshita Y . Inflammatory bowel disease: review from the aspect of genetics. J Gastroenterol. 2009; 44(11):1097-108. DOI: 10.1007/s00535-009-0141-8. View

Barahona-Garrido J, Sarti H, Barahona-Garrido M, Hernandez-Calleros J, Coss-Adame E, Garcia-Saenz S . Serological markers in inflammatory bowel disease: a review of their clinical utility. Rev Gastroenterol Mex. 2009; 74(3):230-7. View

Kobayashi S, Ohno K, Uetsuka K, Nakashima K, Setoguchi A, Fujino Y . Measurement of intestinal mucosal permeability in dogs with lymphocytic-plasmacytic enteritis. J Vet Med Sci. 2007; 69(7):745-9. DOI: 10.1292/jvms.69.745. View

10.

Jergens A . Clinical assessment of disease activity for canine inflammatory bowel disease. J Am Anim Hosp Assoc. 2004; 40(6):437-45. DOI: 10.5326/0400437. View

11.

Packey C, Sartor R . Interplay of commensal and pathogenic bacteria, genetic mutations, and immunoregulatory defects in the pathogenesis of inflammatory bowel diseases. J Intern Med. 2008; 263(6):597-606. DOI: 10.1111/j.1365-2796.2008.01962.x. View

12.

Schreiner N, Gaschen F, Grone A, Sauter S, Allenspach K . Clinical signs, histology, and CD3-positive cells before and after treatment of dogs with chronic enteropathies. J Vet Intern Med. 2008; 22(5):1079-83. DOI: 10.1111/j.1939-1676.2008.0153.x. View

13.

Gunawardana S, Jergens A, Ahrens F, Niyo Y . Colonic nitrite and immunoglobulin G concentrations in dogs with inflammatory bowel disease. J Am Vet Med Assoc. 1997; 211(3):318-21. View

14.

Langhorst J, Elsenbruch S, Koelzer J, Rueffer A, Michalsen A, Dobos G . Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices. Am J Gastroenterol. 2007; 103(1):162-9. DOI: 10.1111/j.1572-0241.2007.01556.x. View

15.

Abraham C, Cho J . Interleukin-23/Th17 pathways and inflammatory bowel disease. Inflamm Bowel Dis. 2009; 15(7):1090-100. DOI: 10.1002/ibd.20894. View

16.

Rychlik A, Nieradka R, Kander M, Depta A, Nowicki M, Sarti K . Usefulness of endoscopic examination for the diagnosis of inflammatory bowel disease in the dog. Pol J Vet Sci. 2007; 10(2):113-8. View

17.

Day M, Bilzer T, Mansell J, Wilcock B, Hall E, Jergens A . Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: a report from the World Small Animal Veterinary Association Gastrointestinal Standardization Group. J Comp Pathol. 2008; 138 Suppl 1:S1-43. DOI: 10.1016/j.jcpa.2008.01.001. View

18.

Nikoopour E, Schwartz J, Singh B . Therapeutic benefits of regulating inflammation in autoimmunity. Inflamm Allergy Drug Targets. 2008; 7(3):203-10. DOI: 10.2174/187152808785748155. View

19.

Suchodolski J, Steiner J . Laboratory assessment of gastrointestinal function. Clin Tech Small Anim Pract. 2004; 18(4):203-10. DOI: 10.1016/S1096-2867(03)00075-6. View

20.

German A, Hall E, Day M . Immune cell populations within the duodenal mucosa of dogs with enteropathies. J Vet Intern Med. 2001; 15(1):14-25. DOI: 10.1892/0891-6640(2001)015<0014:icpwtd>2.3.co;2. View