The Rate of Unequal Crossing over in the Dumpy Gene from Drosophila Melanogaster

Overview

Journal J Mol Evol

Specialty Biochemistry

Date 2010 Mar 6

PMID 20204610

Citations 7

Authors

Amber Carmon

Matthew Larson

Marta Wayne

Ross MacIntyre

Affiliations

Soon will be listed here.

Abstract

The PIGSFEAST (PF) exon of the Drosophila dumpy gene is undergoing concerted evolution by the process of unequal crossing over. We have developed a long-range PCR-based assay to amplify the approximately 12 kb long exon which contains variable numbers of 303 or 306 nt long repeats in a tandem array. We applied this procedure to mutation accumulation lines of Drosophila melanogaster established by M. Wayne and L. Higgins. Nine new repeat length variants were found in these lines allowing us to measure the rate of unequal crossing over in the PF exon. The rate, which for several reasons is an underestimate, is 7.05 x 10(-4) exchanges per generation.

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