» Articles » PMID: 20202892

Expanding the Range of 'druggable' Targets with Natural Product-based Libraries: an Academic Perspective

Overview
Publisher Elsevier
Specialty Biochemistry
Date 2010 Mar 6
PMID 20202892
Citations 69
Authors
Affiliations
Soon will be listed here.
Abstract

Existing drugs address a relatively narrow range of biological targets. As a result, libraries of drug-like molecules have proven ineffective against a variety of challenging targets, such as protein-protein interactions, nucleic acid complexes, and antibacterial modalities. In contrast, natural products are known to be effective at modulating such targets, and new libraries are being developed based on underrepresented scaffolds and regions of chemical space associated with natural products. This has led to several recent successes in identifying new chemical probes that address these challenging targets.

Citing Articles

Antibacterial Potential of Ethyl 3,5-Dibromoorsellinate, a Derivative of Diphenyl Ethers from , against Methicillin-Resistant .

Nguyen D, Duong T, Nguyen T, Nguyen H, Nguyen C ACS Omega. 2024; 9(50):50012-50023.

PMID: 39713661 PMC: 11656388. DOI: 10.1021/acsomega.4c09518.


A divergent intermediate strategy yields biologically diverse pseudo-natural products.

Bag S, Liu J, Patil S, Bonowski J, Koska S, Scholermann B Nat Chem. 2024; 16(6):945-958.

PMID: 38365941 PMC: 11164679. DOI: 10.1038/s41557-024-01458-4.


Clinical development and informatics analysis of natural and semi-synthetic flavonoid drugs: A critical review.

Xu K, Ren X, Wang J, Zhang Q, Fu X, Zhang P J Adv Res. 2023; 63:269-284.

PMID: 37949300 PMC: 11380023. DOI: 10.1016/j.jare.2023.11.007.


Biocatalysis in Drug Design: Engineered Reductive Aminases (RedAms) Are Used to Access Chiral Building Blocks with Multiple Stereocenters.

Rue Casamajo A, Yu Y, Schnepel C, Morrill C, Barker R, Levy C J Am Chem Soc. 2023; 145(40):22041-22046.

PMID: 37782882 PMC: 10571080. DOI: 10.1021/jacs.3c07010.


High-Throughput Screening of Natural Product and Synthetic Molecule Libraries for Antibacterial Drug Discovery.

Ayon N Metabolites. 2023; 13(5).

PMID: 37233666 PMC: 10220967. DOI: 10.3390/metabo13050625.


References
1.
Peng L, Stanton B, Maloof N, Wang X, Schreiber S . Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog. Bioorg Med Chem Lett. 2009; 19(22):6319-25. PMC: 2796117. DOI: 10.1016/j.bmcl.2009.09.089. View

2.
Driggers E, Hale S, Lee J, Terrett N . The exploration of macrocycles for drug discovery--an underexploited structural class. Nat Rev Drug Discov. 2008; 7(7):608-24. DOI: 10.1038/nrd2590. View

3.
Kotake Y, Sagane K, Owa T, Mimori-Kiyosue Y, Shimizu H, Uesugi M . Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat Chem Biol. 2007; 3(9):570-5. DOI: 10.1038/nchembio.2007.16. View

4.
Newman D, Cragg G, Snader K . Natural products as sources of new drugs over the period 1981-2002. J Nat Prod. 2003; 66(7):1022-37. DOI: 10.1021/np030096l. View

5.
Hert J, Irwin J, Laggner C, Keiser M, Shoichet B . Quantifying biogenic bias in screening libraries. Nat Chem Biol. 2009; 5(7):479-83. PMC: 2783405. DOI: 10.1038/nchembio.180. View