A Systems Biology Approach to Understanding Atherosclerosis

Overview

Journal EMBO Mol Med

Specialty Molecular Biology

Date 2010 Mar 5

PMID 20201031

Citations 31

Authors

Stephen A Ramsey

Elizabeth S Gold

Alan Aderem

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis, a chronic inflammatory disease of the vascular system, presents significant challenges to developing effective molecular diagnostics and novel therapies. A systems biology approach integrating data from large-scale measurements (e.g. transcriptomics, proteomics and genomics) is successfully contributing to deciphering regulatory networks underlying the response of many different cellular systems to perturbations. Such a network analysis strategy using pathway information and data from multiple measurement platforms, tissues and species is a promising approach to elucidate the mechanistic underpinnings of complex diseases. Here, we present our views on the contributions that a systems approach can bring to the study of atherosclerosis, propose ways to tackle the complexity of the disease in a systems manner and review recent systems-level studies of the disease.

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