Inflammasomes As Microbial Sensors

Overview

Journal Eur J Immunol

Specialty Allergy & Immunology

Date 2010 Mar 5

PMID 20201013

Citations 69

Authors

Luigi Franchi

Raul Munoz-Planillo

Thornik Reimer

Tatjana Eigenbrod

Gabriel Nunez

Affiliations

Soon will be listed here.

Abstract

Members of the Nod-like receptor family and the adaptor ASC assemble into multiprotein platforms, termed inflammasomes, to mediate the activation of caspase-1 and subsequent secretion of IL-1beta and IL-18. Recent studies have identified microbial and endogenous molecules as well as possible mechanisms involved in inflammasome activation.

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