Alpha 2.0
Login Register
» Articles » PMID: 20195440

Aflatoxin Contamination in Food and Body Fluids in Relation to Malnutrition and Cancer Status in Cameroon

Overview
Journal Int J Environ Res Public Health
Publisher MDPI
Specialties Environmental Health
Public Health
Date 2010 Mar 3
PMID 20195440
Citations 38
Authors
Angele N Tchana
Paul F Moundipa
Felicite M Tchouanguep
Affiliations
Soon will be listed here.
Abstract

Aflatoxins are food contaminants usually associated with hepatitis, immunodepression, impairment of fertility and cancer. The present work was to determine the presence of aflatoxins in eggs, milk, urine, and blood samples that were collected from various sources and periods; and hepatitis B virus antigen in blood samples. Aflatoxin was found in eggs (45.2%), cow raw milk (15.9%), breast milk (4.8%), urine from kwashiorkor and marasmic kwashiorkor children (45.5%), and sera from primary liver cancer patients (63.9%); HbsAg was also detected in 69.4% of the serum samples, but there was no association between both factors. Both AF and hepatitis B virus seem to be risk factors that could increase the incidence and prevalence rates of malnutrition and cancer in Cameroon.

Citing Articles

An untargeted metabolomic analysis of acute AFB1 treatment in liver, breast, and lung cells.

Cao H, Molina S, Sumner S, Rushing B PLoS One. 2025; 20(1):e0313159.

PMID: 39883710 PMC: 11781672. DOI: 10.1371/journal.pone.0313159.

Aflatoxins and fumonisins co-contamination effects on laying hens and use of mycotoxin detoxifiers as a mitigation strategy.

Ochieng P, Kemboi D, Okoth S, De Baere S, Cavalier E, Kangethe E Mycotoxin Res. 2024; 41(1):63-75.

PMID: 39402398 PMC: 11759475. DOI: 10.1007/s12550-024-00566-x.

Prevalence and concentration of aflatoxin M in breast milk in Africa: a meta-analysis and implication for the interface of agriculture and health.

Hassen J, Debella A, Eyeberu A, Mussa I Sci Rep. 2024; 14(1):16611.

PMID: 39025909 PMC: 11258143. DOI: 10.1038/s41598-024-59534-1.

The occurrence and human health risk assessment of total and aflatoxin B in selected food commodities in Bhutan.

Monger A, Mongar P, Dorji T, Chhetri V Sci Rep. 2024; 14(1):16258.

PMID: 39009623 PMC: 11251174. DOI: 10.1038/s41598-024-63677-6.

Fungal profile, levels of aflatoxin M1, exposure, and the risk characterization of local cheese '' consumed in the Ho Municipality, Volta Region, Ghana.

Kortei N, Gillette V, Wiafe-Kwagyan M, Ansah L, Kyei-Baffour V, Odamtten G Toxicol Rep. 2024; 12:186-199.

PMID: 38313814 PMC: 10837644. DOI: 10.1016/j.toxrep.2024.01.009.

References
1.
Loveland P, Wilcox J, Hendricks J, Bailey G . Comparative metabolism and DNA binding of aflatoxin B1, aflatoxin M1, aflatoxicol and aflatoxicol-M1 in hepatocytes from rainbow trout (Salmo gairdneri). Carcinogenesis. 1988; 9(3):441-6. DOI: 10.1093/carcin/9.3.441. View
2.
Anukarahanonta T, Chudhabuddhi C . High-performance liquid chromatography of aflatoxins in human urine. J Chromatogr. 1983; 275(2):387-93. DOI: 10.1016/s0378-4347(00)84384-4. View
3.
Jiang Y, Jolly P, Ellis W, Wang J, Phillips T, Williams J . Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians. Int Immunol. 2005; 17(6):807-14. DOI: 10.1093/intimm/dxh262. View
4.
MOULE Y . [Metabolic transformation of aflatoxin B-1 and its effects on synthesis of nucleic acids and proteins]. Ann Nutr Aliment. 1974; 28(4):375-84. View
5.
Perera F . Molecular epidemiology: on the path to prevention?. J Natl Cancer Inst. 2000; 92(8):602-12. DOI: 10.1093/jnci/92.8.602. View