Risk Factors for Periventricular-intraventricular Hemorrhage in Premature Infants

Overview

Journal J Korean Med Sci

Specialty General Medicine

Date 2010 Mar 2

PMID 20191041

Citations 22

Authors

Ju Young Lee

Han Suk Kim

Euiseok Jung

Eun Sun Kim

Gyu Hong Shim

Hyun Joo Lee

Jin A Lee

Chang Won Choi

Ee-Kyung Kim

Beyong Il Kim

Jung-Hwan Choi

Affiliations

Soon will be listed here.

Abstract

Periventricular-intraventricular hemorrhage (PV-IVH) is a major cause of neurological disabilities in preterm newborns. This study aimed to determine the perinatal factors associated with PV-IVH. We conducted a retrospective case-control study from preterm infants born at < or =34 weeks of gestation and admitted to Neonatal Intensive Care Units of Seoul National University Children's Hospital and Seoul National University Bundang Hospital between June 2003 and December 2007. Neonates with no cranial sonographic data or infants transferred from other centers after three days of age were excluded. Of 1,044 eligible subjects, 59 infants with PV-IVH grade 2, 3, and 4 were allocated to the case group. The control group consisted of 118 infants without PV-IVH who were matched for gestational age and birth weight to each case of PV-IVH. At the multivariate logistic regression model, metabolic acidosis (odds ratio [OR]: 6.94; 95% confidence interval [CI]: 1.12-43.23) and use of inotropes (OR: 3.70; 95% CI: 1.16-11.84) were associated with an increased risk of PV-IVH. Maternal use of antenatal corticosteroids decreases the risk of PV-IVH (OR: 0.36; 95% CI: 0.14-0.92).

Citing Articles

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Incidence and Risk Factors of Intraventricular Hemorrhage in Early Preterm Infants: A Cross-Sectional Study.

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