Sex-specific Responses to Stroke

Overview

Journal Future Neurol

Specialty Neurology

Date 2010 Mar 2

PMID 20190872

Citations 33

Authors

L Christine Turtzo

Louise D McCullough

Affiliations

Soon will be listed here.

Abstract

Stroke is a sexually dimorphic disease, with differences between males and females observed both clinically and in the laboratory. While males have a higher incidence of stroke throughout much of the lifespan, aged females have a higher burden of stroke. Sex differences in stroke result from a combination of factors, including elements intrinsic to the sex chromosomes as well as the effects of sex hormone exposure throughout the lifespan. Research investigating the sexual dimorphism of stroke is only in the beginning stages, but early findings suggest that different cell death pathways are activated in males and females after ischemic stroke. A greater understanding of the mechanisms underlying sex differences in stroke will lead to more appropriate treatment strategies for patients of both sexes.

Citing Articles

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