SprB is the Molecular Link Between Salmonella Pathogenicity Island 1 (SPI1) and SPI4

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2010 Mar 2

PMID 20190046

Citations 13

Authors

Supreet Saini

Christopher V Rao

Affiliations

Soon will be listed here.

Abstract

Salmonella pathogenicity island 1 (SPI1) and SPI4 have previously been shown to be jointly regulated. We report that SPI1 and SPI4 gene expression is linked through a transcriptional activator, SprB, encoded within SPI1 and regulated by HilA. SprB directly activates SPI4 gene expression and weakly represses SPI1 gene expression through HilD.

Citing Articles

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Two Additional Connections between the Transcriptional Programs Controlling Invasion and Intracellular Replication of Salmonella: HilD-SprB Positively Regulates and .

Banda M, Perez-Morales D, Zavala-Alvarado C, Nava-Galeana J, Bustamante V J Bacteriol. 2022; 204(11):e0020422.

PMID: 36214553 PMC: 9664945. DOI: 10.1128/jb.00204-22.

Prophage-mediated genome differentiation of the Derby ST71 population.

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HilD induces expression of a novel Salmonella Typhimurium invasion factor, YobH, through a regulatory cascade involving SprB.

Banda M, Manzo R, Bustamante V Sci Rep. 2019; 9(1):12725.

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Inorganic Polyphosphate Is Essential for Typhimurium Virulence and Survival in .

Varas M, Riquelme-Barrios S, Valenzuela C, Marcoleta A, Berrios-Pasten C, Santiviago C Front Cell Infect Microbiol. 2018; 8:8.

PMID: 29441327 PMC: 5797601. DOI: 10.3389/fcimb.2018.00008.

References

de Keersmaecker S, Marchal K, Verhoeven T, Engelen K, Vanderleyden J, Detweiler C . Microarray analysis and motif detection reveal new targets of the Salmonella enterica serovar Typhimurium HilA regulatory protein, including hilA itself. J Bacteriol. 2005; 187(13):4381-91. PMC: 1151768. DOI: 10.1128/JB.187.13.4381-4391.2005. View

Main-Hester K, Colpitts K, Thomas G, Fang F, Libby S . Coordinate regulation of Salmonella pathogenicity island 1 (SPI1) and SPI4 in Salmonella enterica serovar Typhimurium. Infect Immun. 2007; 76(3):1024-35. PMC: 2258849. DOI: 10.1128/IAI.01224-07. View

Kiss T, Morgan E, Nagy G . Contribution of SPI-4 genes to the virulence of Salmonella enterica. FEMS Microbiol Lett. 2007; 275(1):153-9. DOI: 10.1111/j.1574-6968.2007.00871.x. View

Boddicker J, Knosp B, Jones B . Transcription of the Salmonella invasion gene activator, hilA, requires HilD activation in the absence of negative regulators. J Bacteriol. 2003; 185(2):525-33. PMC: 145326. DOI: 10.1128/JB.185.2.525-533.2003. View

Ellermeier C, Slauch J . RtsA and RtsB coordinately regulate expression of the invasion and flagellar genes in Salmonella enterica serovar Typhimurium. J Bacteriol. 2003; 185(17):5096-108. PMC: 181000. DOI: 10.1128/JB.185.17.5096-5108.2003. View

Nagai T, Ibata K, Park E, Kubota M, Mikoshiba K, Miyawaki A . A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nat Biotechnol. 2001; 20(1):87-90. DOI: 10.1038/nbt0102-87. View

Ahmer B, Van Reeuwijk J, Watson P, Wallis T, Heffron F . Salmonella SirA is a global regulator of genes mediating enteropathogenesis. Mol Microbiol. 1999; 31(3):971-82. DOI: 10.1046/j.1365-2958.1999.01244.x. View

Lawley T, Chan K, Thompson L, Kim C, Govoni G, Monack D . Genome-wide screen for Salmonella genes required for long-term systemic infection of the mouse. PLoS Pathog. 2006; 2(2):e11. PMC: 1383486. DOI: 10.1371/journal.ppat.0020011. View

Kimbrough T, MILLER S . Contribution of Salmonella typhimurium type III secretion components to needle complex formation. Proc Natl Acad Sci U S A. 2000; 97(20):11008-13. PMC: 27139. DOI: 10.1073/pnas.200209497. View

10.

Ellermeier J, Slauch J . Adaptation to the host environment: regulation of the SPI1 type III secretion system in Salmonella enterica serovar Typhimurium. Curr Opin Microbiol. 2007; 10(1):24-9. DOI: 10.1016/j.mib.2006.12.002. View

11.

Lostroh C, Lee C . The Salmonella pathogenicity island-1 type III secretion system. Microbes Infect. 2002; 3(14-15):1281-91. DOI: 10.1016/s1286-4579(01)01488-5. View

12.

Lostroh C, Lee C . The HilA box and sequences outside it determine the magnitude of HilA-dependent activation of P(prgH) from Salmonella pathogenicity island 1. J Bacteriol. 2001; 183(16):4876-85. PMC: 99542. DOI: 10.1128/JB.183.16.4876-4885.2001. View

13.

Sukhan A, Kubori T, Wilson J, Galan J . Genetic analysis of assembly of the Salmonella enterica serovar Typhimurium type III secretion-associated needle complex. J Bacteriol. 2001; 183(4):1159-67. PMC: 94988. DOI: 10.1128/JB.183.4.1159-1167.2001. View

14.

Ellermeier C, Ellermeier J, Slauch J . HilD, HilC and RtsA constitute a feed forward loop that controls expression of the SPI1 type three secretion system regulator hilA in Salmonella enterica serovar Typhimurium. Mol Microbiol. 2005; 57(3):691-705. DOI: 10.1111/j.1365-2958.2005.04737.x. View

15.

Galan J . Interaction of Salmonella with host cells through the centisome 63 type III secretion system. Curr Opin Microbiol. 1999; 2(1):46-50. DOI: 10.1016/s1369-5274(99)80008-3. View

16.

Karlinsey J . lambda-Red genetic engineering in Salmonella enterica serovar Typhimurium. Methods Enzymol. 2007; 421:199-209. DOI: 10.1016/S0076-6879(06)21016-4. View

17.

Gerlach R, Jackel D, Stecher B, Wagner C, Lupas A, Hardt W . Salmonella Pathogenicity Island 4 encodes a giant non-fimbrial adhesin and the cognate type 1 secretion system. Cell Microbiol. 2007; 9(7):1834-50. DOI: 10.1111/j.1462-5822.2007.00919.x. View

18.

Morgan E, Campbell J, Rowe S, Bispham J, Stevens M, Bowen A . Identification of host-specific colonization factors of Salmonella enterica serovar Typhimurium. Mol Microbiol. 2004; 54(4):994-1010. DOI: 10.1111/j.1365-2958.2004.04323.x. View

19.

Saini S, Brown J, Aldridge P, Rao C . FliZ Is a posttranslational activator of FlhD4C2-dependent flagellar gene expression. J Bacteriol. 2008; 190(14):4979-88. PMC: 2447003. DOI: 10.1128/JB.01996-07. View

20.

Eichelberg K, Hardt W, Galan J . Characterization of SprA, an AraC-like transcriptional regulator encoded within the Salmonella typhimurium pathogenicity island 1. Mol Microbiol. 1999; 33(1):139-52. DOI: 10.1046/j.1365-2958.1999.01458.x. View