Purinergic Signalling and Bone Remodelling

Overview

Journal Curr Opin Pharmacol

Specialty Pharmacology

Date 2010 Mar 2

PMID 20189453

Citations 67

Authors

Isabel R Orriss

Geoffrey Burnstock

Timothy R Arnett

Affiliations

Soon will be listed here.

Abstract

Accumulating evidence suggests that extracellular nucleotides, signalling through P2 receptors, could play an important role in modulating bone cell function. ATP and other nucleotides can stimulate the formation and resorptive activity of osteoclasts (bone-destroying cells) in addition to inhibiting bone mineralisation by osteoblasts. This review discusses the current understanding of the effects of extracellular nucleotides on skeletal cells.

Citing Articles

Mechanical stimulation-induced purinome priming fosters osteogenic differentiation and osteointegration of mesenchymal stem cells from the bone marrow of post-menopausal women.

Bessa-Andres C, Pinto-Cardoso R, Tarasova K, Pereira-Goncalves A, Gaio-Ferreira-Castro J, Carvalho L Stem Cell Res Ther. 2024; 15(1):168.

PMID: 38886849 PMC: 11184869. DOI: 10.1186/s13287-024-03775-4.

β,γ-Methylene-ATP and its metabolite medronic acid affect both arterial media calcification and bone mineralization in non-CKD and CKD rats.

Opdebeeck B, Van den Branden A, Adriaensen S, Orriss I, Patel J, Geryl H JBMR Plus. 2024; 8(6):ziae057.

PMID: 38764790 PMC: 11102572. DOI: 10.1093/jbmrpl/ziae057.

Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status.

Nandy A, Helderman R, Thapa S, Jayapalan S, Richards A, Narayani N Bone Res. 2023; 11(1):62.

PMID: 38001111 PMC: 10673934. DOI: 10.1038/s41413-023-00297-2.

Extracellular adenosine signaling in bone health and disease.

Newman H, Varghese S Curr Opin Pharmacol. 2023; 70:102378.

PMID: 37044008 PMC: 10247430. DOI: 10.1016/j.coph.2023.102378.

Purinergic signaling: Diverse effects and therapeutic potential in cancer.

Kaur J, Dora S Front Oncol. 2023; 13:1058371.

PMID: 36741002 PMC: 9889871. DOI: 10.3389/fonc.2023.1058371.